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TNFSF13B molecular target information overview


  • Molecular name:TNFSF13B, TNF superfamily member 13b
  • Gene family:CD molecules; Tumor necrosis factor superfamily
  • Alias:BAFF; THANK; BLYS; TALL-1; TALL1; CD257
  • Former name: TNFSF20
  • Alias: B-cell-activating factor; TNF and ApoL-related leukocyte expressed ligand 1; TNF homolog that activates apoptosis; B-lymphocyte stimulator; tumor necrosis factor (ligand) superfamily, member 13b


    • Overview of TNFSF13B molecular targets


    cell activating factor (BAFF), also known as B lymphocyte stimulating factor (BLys) or tumor necrosis factor ligand superfamily member 13B (TNFSF13B), is expressed in cells of the B cell lineage and acts as an effective B cell activator, playing an important role in the proliferation and differentiation of B cells. BAFF is an immunostimulant and is necessary for maintaining normal immunity. Insufficient BAFF expression will fail to activate B cells to produce enough immunoglobulins and lead to immunodeficiency. Excessive BAFF expression can cause excessive antibody secretion, leading to systemic lupus erythematosus, rheumatoid arthritis and other autoimmune diseases.


    Human TNFSF13B Molecular Target Information


    Molecular name: TNFSF13B, TNF superfamily member 13b


    Alias:

    • ApoL related ligand TALL-1
    • b lymphocyte stimulator
    • B-cell activating factor
    • B-cell-activating factor
    • B-lymphocyte stimulator
    • BAFF
    • BLYS
    • CD257
    • delta BAFF
    • Delta4 BAFF
    • dendritic cell-derived TNF-like molecule
    • DTL
    • TALL-1
    • TALL1
    • THANK
    • TNF and ApoL-related leukocyte expressed ligand 1
    • TNF homolog that activates apoptosis
    • TNF- and APOL-related leukocyte expressed ligand 1
    • TNFSF20
    • TNLG7A
    • tumor necrosis factor (ligand) superfamily member 13b
    • tumor necrosis factor (ligand) superfamily, member 13b
    • tumor necrosis factor (ligand) superfamily, member 20
    • tumor necrosis factor ligand 7A
    • tumor necrosis factor ligand superfamily member 13B
    • tumor necrosis factor superfamily member 13b
    • tumor necrosis factor superfamily, member 13b
    • tumor necrosis factor-like protein ZTNF4
    • ZTNF4

    Gene sequence:NCBI_Gene: 10673

    Protein sequence: UniProtKB: Q9Y275


    Human TNFSF13B target molecular function (prediction)


    Predicted to enable receptor ligand activity. Involved in positive regulation of B cell proliferation. Located in several cellular components, including focal adhesion; perinuclear region of cytoplasm; and plasma membrane.


    Mouse Tnfsf13b molecular target information


    Molecular name:Tnfsf13b, tumor necrosis factor (ligand) superfamily, member 13b


    Alias:

    • BAFF
    • BLyS
    • D8Ertd387e
    • DNA segment, Chr 8, ERATO Doi 387, expressed
    • TALL-1
    • zTNF4


    Gene sequence:NCBI_Gene: 24099

    Protein sequence:


    Mouse Tnfsf13b target molecular function (prediction)


    Predicted to enable receptor ligand activity. Involved in B cell differentiation and tumor necrosis factor-mediated signaling pathway. Acts upstream of or within B cell homeostasis; positive regulation of germinal center formation; and positive regulation of lymphocyte activation. Predicted to be located in several cellular components, including focal adhesion; perinuclear region of cytoplasm; and plasma membrane. Predicted to be active in extracellular space. Is expressed in genitourinary system. Used to study IgA glomerulonephritis and Sjogren's syndrome. Orthologous to human TNFSF13B (TNF superfamily member 13b).


    Rat Tnfsf13b molecular target information


    Molecular name: Tnfsf13b, TNF superfamily member 13b

    Alias:

    • B-cell-activating factor
    • BAFF
    • LOC498666
    • RGD1561519
    • similar to NZB B-cell activating factor
    • Tnlg7a
    • tumor necrosis factor (ligand) superfamily, member 13b
    • tumor necrosis factor ligand 7a
    • tumor necrosis factor ligand superfamily member 13B
    • tumor necrosis factor superfamily member 13b

    Gene sequence:NCBI_Gene: 498666

    Protein sequence:


    Rat Tnfsf13b target molecular function (prediction)


    Predicted to enable receptor ligand activity. Predicted to be involved in B cell differentiation; positive regulation of B cell proliferation; and tumor necrosis factor-mediated signaling pathway. Predicted to act upstream of or within B cell homeostasis; positive regulation of germinal center formation; and positive regulation of lymphocyte activation. Predicted to be located in several cellular components, including focal adhesion; perinuclear region of cytoplasm; and plasma membrane. Orthologous to human TNFSF13B (TNF superfamily member 13b).