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CXCL2 Molecular Target Information Overview


  • Molecular name: CXCL2, CXC motif chemokine ligand 2
  • Gene family: Chemokine ligands
  • Other names: SCYB2; GROb; MIP-2a; MGSA-b; CINC-2a
  • Former name: GRO2
  • Alias: GRO2 oncogene; chemokine (CXC motif) ligand 2


    • CXCL2 molecular target review


    Human growth-regulated oncogene β (GRO-β), also known as CXCL2, is a member of the CXC protein chemokine family. GRO-β is also known as MIP-2 in mice and CINC-3 in rats. Human GRO-β is composed of 107 amino acids (aa) and has a molecular weight of approximately 11 kDa. GRO-β is secreted by a variety of cells (including monocytes and macrophages) at the site of inflammation and has a chemotactic effect on granulocytes including neutrophils. GRO-β plays an important role in the inflammatory response and injury repair process. Studies have gradually found that GRO is a proto-oncogene. As an expression product, GRO-β plays a key role in angiogenesis, tumor formation and metastasis, and the interaction between tumors and immune cells.


    Human CXCL2 Molecular Target Information


    Molecular name: CXCL2, CXC motif chemokine ligand 2


    Alias:

    • CXC motif chemokine 2
    • chemokine (CXC motif) ligand 2
    • CINC-2a
    • gro-beta
    • GRO2
    • GRO2 oncogene
    • GROb
    • growth-regulated protein beta
    • macrophage inflammatory protein 2-alpha
    • melanoma growth stimulatory activity beta
    • MGSA beta
    • MGSA-b
    • MIP-2a
    • MIP2
    • MIP2-alpha
    • MIP2A
    • SCYB2

    Gene sequence:NCBI_Gene: 2920

    Protein sequence:UniProtKB: P19875


    Human CXCL2 target molecular function (prediction)


    Predicted to enable CXCR chemokine receptor binding activity and chemokine activity. Involved in antimicrobial humoral immune response mediated by antimicrobial peptide; killing of cells of other organism; and response to molecule of bacterial origin. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Biomarker of COVID-19 and cystic fibrosis.


    Mouse Cxcl2 molecular target information


    Molecular name: Cxcl2, chemokine (CXC motif) ligand 2


    Alias:

    • CINC-2a
    • Gro2
    • GROb
    • macrophage inflammatory protein 2
    • Mgsa-b
    • MIP-2
    • MIP-2a
    • Mip2
    • Scyb
    • Scyb2
    • small inducible cytokine B subfamily
    • small inducible cytokine subfamily, member 2


    Gene sequence:NCBI_Gene: 20310

    Protein sequence:


    Mouse Cxcl2 target molecular function (prediction)


    Predicted to enable CXCR chemokine receptor binding activity and chemokine activity. Involved in response to molecule of bacterial origin. Located in extracellular space. Is expressed in several structures, including alimentary system; embryo mesenchyme; floor plate; respiratory system; and skin. Orthologous to several human genes including CXCL3 (CXC motif chemokine ligand 3).


    Rat Cxcl2 molecular target information


    Molecular name: Cxcl2, CXC motif chemokine ligand 2

    Alias:

    • CXC motif chemokine 2
    • chemokine (CXC motif) ligand 2
    • CINC-3
    • cytokine-induced neutrophil chemoattractant 3
    • macrophage inflammatory protein 2
    • Mip-2
    • MIP2
    • Scyb2
    • small inducible cytokine subfamily, member 2
    • small inducible cytokine subfamily, member 2

    Gene sequence:NCBI_Gene: 114105

    Protein sequence: UniProtKB: P30348


    Rat Cxcl2 target molecular function (prediction)


    Enables chemokine activity. Involved in several processes, including cellular response to interleukin-1; cellular response to lipopolysaccharide; and neutrophil chemotaxis. Located in extracellular space. Biomarker of several diseases, including acute necrotizing pancreatitis; bile duct disease (multiple); brain edema; pleurisy; 2).