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CCN2 molecular target information overview


  • Molecular name: CCN2, cellular communication network factor 2
  • Gene family: Cellular communication network factors
  • Alias: IGFBP8
  • Former name: CTGF
  • Alias: connective tissue growth factor


    • CCN2 molecular target review


    Connective tissue growth factor (CTGF) is a cytoskeletal protein in the CNN family. The extracellular portion of CTGF includes four conserved, cysteine-rich domains: an insulin-like growth factor binding protein (IGFBP) domain, a von Willebrand type C repeat (vWC) domain, a thrombospondin type 1 repeat (TSR) domain, and a C-terminal domain (CT) containing a cysteine motif. CTGF plays an important role in many biological processes, including cell adhesion, migration, proliferation, angiogenesis, bone development, and tissue wound repair. Monitoring CTGF levels in serum can provide more detailed insights into some pathological conditions such as malignancies, diabetic nephropathy, retinopathy, fibrosis, arthritis, pancreatic cancer, and cardiovascular disease.


    Human CCN2 Molecular Target Information


    Molecular name:CCN2, cellular communication network factor 2


    Alias:

    • CCN family member 2
    • connective tissue growth factor
    • CTGF
    • HCS24
    • hypertrophic chondrocyte-specific protein 24
    • IBP-8
    • IGF-binding protein 8
    • IGFBP-8
    • IGFBP8
    • insulin-like growth factor-binding protein 8
    • MGC102839
    • NOV2

    Gene sequence:NCBI_Gene: 1490

    Protein sequence:UniProtKB: P29279


    Human CCN2 target molecular function (prediction)


    Enables protein C-terminus binding activity. Involved in positive regulation of MAPK cascade; positive regulation of cell differentiation; and positive regulation of stress fiber assembly. Colocalizes with collagen-containing extracellular matrix. Biomarker of ovarian cancer.


    Mouse Ccn2 molecular target information


    Molecular name:Ccn2, cellular communication network factor 2


    Alias:

    • connective tissue growth factor
    • Ctgf
    • fibroblast inducible secreted protein
    • Fisp12
    • Hcs24
    • hypertrophic chondrocyte-specific gene product 24


    Gene sequence:NCBI_Gene: 14219

    Protein sequence:


    Mouse Ccn2 target molecular function (prediction)


    Enables heparin binding activity and integrin binding activity. Acts upstream of or within several processes, including cartilage condensation; cell surface receptor signaling pathway; and chondrocyte proliferation. Located in extracellular matrix and extracellular region. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; sensory organ; and skeleton. Orthologous to human CCN2 (cellular communication network factor 2).


    Rat Ccn2 molecular target information


    Molecular name:Ccn2, cellular communication network factor 2

    Also known as:

    • CCN family member 2
    • connective tissue growth factor
    • connective tissue growth-related protein
    • Ctgf
    • CTGRP

    Gene sequence:NCBI_Gene: 64032

    Protein sequence:


    Rat Ccn2 target molecular function (prediction)


    Enables fibronectin binding activity and growth factor activity. Involved in several processes, including positive regulation of G0 to G1 transition; positive regulation of collagen biosynthetic process; and positive regulation of macromolecule metabolic process. Located in several cellular components, including cell cortex; cis-Golgi network; membranoproliferative glomerulonephritis; primary biliary cholangitis; and restrictive cardiomyopathy (multiple). Orthologous to human CCN2 (cellular communication network factor 2).