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IFNB1 molecular target information overview


  • Molecular name: IFNB1, interferon beta 1
  • Gene family: Interferons
  • Synonyms: IFB; IFF
  • Former name: IFNB
  • Alias: interferon, beta 1, fibroblast


    • Overview of IFNB1 molecular targets


    Interferons (IFNs) are a group of signaling proteins synthesized and released by host cells in response to pathogens such as viruses, bacteria, parasites, or tumor cells. Under normal circumstances, virus-infected cells release interferons to enable surrounding cells to improve their antiviral defenses. Based on the receptor type, human interferons can be divided into three major types: type I interferons, including IFN-α, IFN-β, IFN-ε, IFN-κ, and IFN-ω, type II interferons (called IFN-γ in humans), and type III interferons. IFN-β upregulates and downregulates multiple genes through the signaling pathways STAT1 and STAT2, most of which are involved in antiviral immune responses. IFN-β plays an important role in inducing a wide range of nonspecific antiviral infections. It also affects cell proliferation and regulates immune responses.


    Human IFNB1 Molecular Target Information


    Molecular name: IFNB1, interferon beta 1


    Alias:

    • fibroblast interferon
    • IFB
    • IFF
    • IFN-beta
    • IFNB
    • interferon beta
    • interferon-beta
    • interferon, beta 1
    • interferon, beta 1, fibroblast
    • MGC96956

    Gene sequence:NCBI_Gene: 3456

    Protein sequence: UniProtKB: P01574


    Human IFNB1 target molecular function (prediction)


    Enables chloramphenicol O-acetyltransferase activity and cytokine activity. Involved in several processes, including cellular response to cytokine stimulus; negative regulation of T-helper 2 cell cytokine production; and positive regulation of nitrogen compound metabolic process. Acts upstream of or within response to exogenous dsRNA. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Implicated in COVID-19.


    Mouse Ifnb1 molecular target information


    Molecular name: Ifnb1, interferon beta 1, fibroblast


    Alias:

    • Ifb
    • IFN-beta
    • IFNB


    Gene sequence:NCBI_Gene: 15977

    Protein sequence:


    Mouse Ifnb1 target molecular function (prediction)


    Enables cytokine activity and type I interferon receptor binding activity. Involved in B cell proliferation; cellular response to virus; and type I interferon signaling pathway. Acts upstream of or within several processes, including cellular response to organic cyclic compound; defense response to other organism; and negative regulation of osteoclast differentiation. Located in extracellular space. Is expressed in embryo and liver. Human ortholog(s) of this gene implicated in COVID-19. Orthologous to human IFNB1 (interferon beta 1).


    Rat Ifnb1 molecular target information


    Molecular name: Ifnb1, interferon beta 1

    Alias:

    • If1da1
    • IFN-beta
    • Ifnb
    • interferon 1da1
    • interferon beta
    • Interferon beta 1 fibroblast
    • interferon beta 1, fibroblast
    • interferon, beta 1
    • Interferon, beta 1, fibroblast

    Gene sequence:NCBI_Gene: 24481

    Protein sequence:


    Rat Ifnb1 target molecular function (prediction)


    Predicted to enable chloramphenicol O-acetyltransferase activity; cytokine activity; and type I interferon receptor binding activity. Involved in macrophage activation involved in immune response. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in COVID-19. Orthologous to human IFNB1 (interferon beta 1).