EDN1 molecular target information overview
Overview of EDN1 molecular targets
Endothelin-1 (ET-1) is a pleiotropic peptide consisting of 21 amino acid residues. It is originally a 212 amino acid pre-propeptide. Vascular endothelial cells are a rich source of ET-1. The expression of ET-1 in endothelial cells is affected by many factors, including mechanical stimulation, multiple hormones, and proinflammatory cytokines. Endothelin was first identified as an endothelin-derived relaxing factor and then as an endothelin-derived contracting factor. ET-1 stimulates myocardial contraction and myocardial cell growth, regulates the release of vasoactive substances, and stimulates smooth muscle cell mitosis. It also acts as a growth-promoting factor for endothelial cells, and its secretion is regulated by hypothalamic and pituitary cells. ET-1 may control inflammatory responses by promoting the adhesion and migration of neutrophils and stimulating the production of proinflammatory cytokines.
Human EDN1 Molecular Target Information
Molecular name: EDN1, endothelin 1
Alias:
- ARCND3
- endothelin-1
- ET1
- HDLCQ7
- PPET1
- preproendothelin-1
- QME
Gene sequence:NCBI_Gene: 1906
Protein sequence:UniProtKB: P05305
Human EDN1 target molecular function (prediction)
Enables signaling receptor binding activity. Involved in several processes, including intracellular signal transduction; regulation of macromolecule biosynthetic process; and vascular associated smooth muscle contraction. Located in cytoplasm and extracellular space. Implicated in several diseases, including artery disease (multiple); bronchial disease (multiple); obesity; obstructive sleep apnea; and rheumatoid arthritis. Biomarker of several diseases, including artery disease (multiple); autoimmune disease (multiple); glaucoma (multiple); lung disease (multiple); and retinal disease (multiple).
Mouse Edn1 molecular target information
Molecular name: Edn1, endothelin 1
Alias:
- ET-1
Gene sequence:NCBI_Gene: 13614
Protein sequence:
Mouse Edn1 target molecular function (prediction)
Enables endothelin A receptor binding activity. Involved in several processes, including cellular response to gonadotropin stimulus; circulatory system development; and neuron differentiation. Acts upstream of or within several processes, including G protein-coupled receptor signaling pathway; animal organ development; and rhythmic excitation. Located in extracellular space. Is expressed in several structures, including branchial arch; cardiovascular system; central nervous system; gut; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); lung disease (multiple); obesity; obstructive sleep apnea; and rheumatoid arthritis. Orthologous to human EDN1 (endothelin 1).
Rat Edn1 molecular target information
Molecular name: Edn1, endothelin 1
Alias:
- dickkopf 1 homolog
- dickkopf 1 homolog (Xenopus laevis)
- dickkopf homolog 1
- dickkopf homolog 1 (Xenopus laevis)
- dickkopf-like protein 1
- dickkopf-related protein 1
- LOC293897
- NEWGENE_1307313
Gene sequence:NCBI_Gene: 24323
Protein sequence:UniProtKB: P22388
Rat Edn1 target molecular function (prediction)
Predicted to enable co-receptor binding activity; low-density lipoprotein particle receptor binding activity; and receptor antagonist activity. Involved in negative regulation of ossification and positive regulation of neuron death. Located in extracellular space. Used to study visual epilepsy. Human ortholog(s) of this gene implicated in anodontia. Orthologous to human DKK1 (dickkopf WNT signaling pathway inhibitor 1).