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CCL20 molecular target information overview


  • Molecular name: CCL20, CC motif chemokine ligand 20
  • Gene family: Chemokine ligands
  • Alias: LARC; MIP-3a; exodus-1; ST38; CKb4
  • Former name: SCYA20
  • Alias: small inducible cytokine subfamily A (Cys-Cys), member 20; chemokine (CC motif) ligand 20


    • CCL20 molecular target review


    Chemokine ligand 20 (CCL20), also known as macrophage inflammatory protein 3α (MIP-3α), is a small molecular weight cytokine of the CC chemokine family. CCL20 has a strong chemotactic effect on lymphocytes, but a weak chemotactic effect on neutrophils. Monocytes, macrophages, microglia, astrocytes, mast cells, keratinocytes, intestinal epithelial cells, osteoblasts, fibroblasts, endothelial cells and bronchial epithelial cells can express CCL20. CCL20 chemotactic lymphocytes and dendritic cells to the epithelial cells surrounding the mucosal lymphoid tissue, thereby participating in the formation and function of the mucosal lymphoid tissue. CCL20 binds to and activates the chemokine receptor CCR6 to act on target cells. CCL20 may play an important role in the pathogenesis of autoimmune diseases of the central nervous system.


    Human CCL20 Molecular Target Information


    Molecular name: CCL20, CC motif chemokine ligand 20


    Alias:

    • beta chemokine exodus-1
    • beta-chemokine exodus-1
    • CC motif chemokine 20
    • CC chemokine LARC
    • chemokine (CC motif) ligand 20
    • CKb4
    • Exodus
    • exodus-1
    • LARC
    • liver and activation-regulated chemokine
    • macrophage inflammatory protein 3 alpha
    • MIP-3-alpha
    • MIP-3a
    • MIP3A
    • SCYA20
    • small inducible cytokine subfamily A (Cys-Cys), member 20
    • small-inducible cytokine A20
    • ST38

    Gene sequence:NCBI_Gene: 6364

    Protein sequence:UniProtKB: P78556


    Human CCL20 target molecular function (prediction)


    Enables CCR6 chemokine receptor binding activity. Involved in several processes, including antimicrobial humoral immune response mediated by antimicrobial peptide; calcium-mediated signaling using intracellular calcium source; and cell chemotaxis. Acts upstream of or within positive regulation of T cell migration. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Biomarker of several diseases, including IgA glomerulonephritis; Lyme disease; anogenital venereal wart; dermatitis (multiple); and skin papilloma.


    Mouse Ccl20 molecular target information


    Molecular name: Ccl20, chemokine (CC motif) ligand 20


    Alias:

    • CKb4
    • exodus-1
    • MIP-3[a]
    • MIP-3A
    • MIP3A
    • Scya20
    • small inducible cytokine subfamily A20
    • ST38


    Gene sequence:NCBI_Gene: 20297

    Protein sequence:


    Mouse Ccl20 Target Molecular Function (Prediction)


    Enables CCR6 chemokine receptor binding activity and cytokine activity. Involved in chemotaxis and thymocyte migration. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human CCL20 (CC motif chemokine ligand 20).


    Rat Ccl20 molecular target information


    Molecular name: Ccl20, CC motif chemokine ligand 20

    Alias:

    • beta chemokine exodus-1
    • beta-chemokine exodus-1
    • CC motif chemokine 20
    • CC chemokine LARC
    • CC chemokine ST38
    • chemokine (CC motif) ligand 20
    • liver and activation-regulated chemokine
    • macrophage inflammatory protein 3 alpha
    • MIP-3-alpha
    • Scya20
    • small inducible cytokine subfamily A20
    • small-inducible cytokine A20
    • ST38

    Gene sequence:NCBI_Gene: 29538

    Protein sequence:UniProtKB: P97884


    Rat Ccl20 target molecule function (prediction)


    Enables chemokine activity. Involved in several processes, including cellular response to molecule of bacterial origin; positive regulation of macromolecule metabolic process; and wound healing. Located in extracellular space. Used to study transient cerebral ischemia. Biomarker of brain ischemia and ulcerative colitis. Orthologous to human CCL20 (CC motif chemokine ligand 20).