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TNFRSF1A molecular target information overview


  • Molecular name: TNFRSF1A, TNF receptor superfamily member 1A
  • Gene family: CD molecules; Tumor necrosis factor receptor superfamily
  • Alias: TNF-R; TNFAR; TNFR60; TNF-RI; CD120a; TNF-R55
  • Former name: TNFR1
  • Alias: tumor necrosis factor receptor superfamily, member 1A


    • Overview of TNFRSF1A molecular targets


    Tumor necrosis factor receptor 1 (TNFRI), also known as tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) and CD120a, is a member of the tumor necrosis factor receptor superfamily. It can activate the transcription factor NF-κB, mediate apoptosis and regulate inflammation. TNFRI gene mutations are associated with an increased risk of multiple sclerosis. TNFRI levels are elevated in the serum of patients with schizophrenia and bipolar disorder, and high levels of TNFRI are associated with more severe psychotic symptoms.


    Human TNFRSF1A Molecular Target Information


    Molecular name: TNFRSF1A, TNF receptor superfamily member 1A


    Alias:

    • CD120a
    • FPF
    • MGC19588
    • MS5
    • p55
    • p55-R
    • p60
    • TBP1
    • TNF-R
    • TNF-RI
    • TNF-R1
    • TNF-R55
    • TNF-RI
    • TNFAR
    • TNFR-I
    • TNFR1
    • TNFR1-d2
    • TNFR55
    • TNFR60
    • tumor necrosis factor binding protein 1
    • tumor necrosis factor receptor 1
    • tumor necrosis factor receptor 1A isoform beta
    • tumor necrosis factor receptor superfamily, member 1A
    • tumor necrosis factor receptor superfamily, member 1A
    • tumor necrosis factor receptor type 1
    • tumor necrosis factor receptor type I
    • tumor necrosis factor-alpha receptor

    Gene sequence:NCBI_Gene: 7132

    Protein sequence:UniProtKB: P19438


    Human TNFRSF1A target molecular function (prediction)


    Enables tumor necrosis factor binding activity. Involved in several processes, including cellular response to mechanical stimulus; positive regulation of nitrogen compound metabolic process; and tumor necrosis factor-mediated signaling pathway. Located in Golgi membrane; extracellular space; and membrane raft. Part of receptor complex. Implicated in several diseases, including IgA glomerulonephritis; acne; allergic bronchopulmonary aspergillosis; autoimmune disease (multiple); periodic fever. Biomarker of several diseases, including acquired immunodeficiency syndrome; autoimmune disease (multiple); female reproductive organ cancer (multiple); kidney disease (multiple); and lung disease (multiple).


    Mouse Tnfrsf1a molecular target information


    Molecular name:Tnfrsf1a, tumor necrosis factor receptor superfamily, member 1a


    Alias:

    • CD120a
    • p55
    • p55-R
    • TNF receptor alpha chain
    • TNF-alpha-R1
    • TNF-alphaR1
    • TNF-RI
    • TNF-R1
    • TNF-R55
    • TNFalpha-R1
    • TNFAR
    • Tnfr-2
    • Tnfr1
    • TNFR60
    • TNFRI
    • TNFRp55
    • tumor necrosis factor receptor 1
    • tumor necrosis factor receptor 2


    Gene sequence:NCBI_Gene: 21937

    Protein sequence:


    Mouse Tnfrsf1a Target Molecular Function (Prediction)


    Acts upstream of or within several processes, including defense response to bacterium; intrinsic apoptotic signaling pathway in response to DNA damage; and regulation of tumor necrosis factor-mediated signaling pathway. Located in cell surface and membrane raft. Is expressed in several structures, including alimentary system; extraembryonic component; hemolymphoid system; reproductive system; and respiratory system. Used to study autosomal dominant familial periodic fever. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; acne; allergic bronchopulmonary aspergillosis; autoimmune disease (multiple); and autosomal dominant familial periodic fever. Orthologous to human TNFRSF1A (TNF receptor superfamily member 1A).


    Rat Tnfrsf1a molecular target information


    Molecular name: Tnfrsf1a, TNF receptor superfamily member 1A

    Alias:

    • MGC105478
    • p55
    • p60
    • TNF-R1
    • TNF-RI
    • TNFR-1
    • TNFR-I
    • Tnfr1
    • Tumor necrosis factor receptor
    • tumor necrosis factor receptor 1
    • tumor necrosis factor receptor superfamily, member 1A
    • tumor necrosis factor receptor superfamily, member 1a
    • tumor necrosis factor receptor type I

    Gene sequence:NCBI_Gene: 25625

    Protein sequence:


    Rat Tnfrsf1a target molecular function (prediction)


    Enables protease binding activity; tumor necrosis factor binding activity; and tumor necrosis factor-activated receptor activity. Involved in several processes, including cellular response to estradiol stimulus; and regulation of apoptotic process; and regulation of cytokine production. Located in several cellular components, including regulation cell surface; membrane raft; and mitochondrion. Part of protein-containing complex. Used to study ischemia (multiple); middle cerebral artery infarction; myocardial infarction; uveitis; and visual epilepsy. Biomarker of several diseases, including root resorption; sciatic neuropathy; transient cerebral ischemia; type 2 diabetes mellitus; and ureteral obstruction. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; acne; allergic bronchopulmonary aspergillosis; autoimmune disease (multiple); and autosomal dominant familial periodic fever. Orthologous to human TNFRSF1A (TNF receptor superfamily member 1A).