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FLT1 Molecular Target Information Overview


  • Molecular name: FLT1, fms related receptor tyrosine kinase 1
  • Gene family: Receptor tyrosine kinases; I-set domain containing
  • Alias: VEGFR1
  • Previous name: FLT
  • Alias: vascular endothelial growth factor receptor 1; vascular permeability factor receptor; fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor); fms-related tyrosine kinase 1; fms related tyrosine kinase 1


    • Overview of FLT1 molecular targets


    Vascular endothelial growth factor receptor 1 (VEGF R1), also known as Flt-1, is a specific tyrosine kinase (RTK) receptor for the angiogenic factors VEGF (VEGF-A), placental growth factor (PIGF), and VEGF-B. Depending on the shear form, there are two forms: membrane-type (mbVEGFR) and soluble (sVEGFR). Experimental and clinical injections of sVEGF R1 successfully blocked angiogenesis and tumor growth. Under different pathological conditions, the content of sVEGF R1 in serum/plasma varies and may have diagnostic value. Under experimental and pathological conditions, sVEGF R1 and VEGF levels are correlated. High levels of sVEGF R1 are present in the plasma of pregnant women and patients with essential hypertension. The level of sVEGF R1 is significantly reduced in the plasma of patients with cardiovascular disease and smokers.


    Human FLT1 Molecular Target Information


    Molecular name:FLT1, fms related receptor tyrosine kinase 1


    Alias:

    • FLT
    • FLT-1
    • fms related tyrosine kinase 1
    • fms-like tyrosine kinase 1
    • fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
    • tyrosine-protein kinase FRT
    • tyrosine-protein kinase receptor FLT
    • vascular endothelial growth factor receptor 1
    • vascular permeability factor receptor
    • VEGFR-1
    • VEGFR1

    Gene sequence:NCBI_Gene: 2321

    Protein sequence: UniProtKB: P17948


    Human FLT1 target molecular function (prediction)


    Enables growth factor binding activity; placental growth factor-activated receptor activity; and vascular endothelial growth factor-activated receptor activity. Involved in several processes, including monocyte chemotaxis; positive regulation of kinase activity; and protein phosphorylation. Located in actin cytoskeleton and plasma membrane. Is integral component of plasma membrane. Part of receptor complex. Implicated in Kuhnt-Junius degeneration; diabetic retinopathy; and pre-eclampsia. Biomarker of several diseases, including Kawasaki disease; Leydig cell tumor; cerebrovascular disease (multiple); kidney cancer (multiple); and retinal disease (multiple).


    Mouse Flt1 molecular target information


    Molecular Name: Flt1, FMS-like tyrosine kinase 1


    Alternate names:

    • AI323757
    • expressed sequence AI323757
    • Flt-1
    • sFlt1
    • vascular endothelial growth factor receptor-1
    • VEGFR-1
    • VEGFR1


    Gene sequence:NCBI_Gene: 14254

    Protein sequence:


    Mouse Flt1 target molecular function (prediction)


    Acts upstream of or within several processes, including angiogenesis; positive regulation of hematopoietic progenitor cell differentiation; and post-embryonic camera-type eye morphogenesis. Located in extracellular space and nucleus. Is expressed in several structures, including alimentary cardiovascular system; central nervous system; extraembryonic component; and genitourinary system. Human ortholog(s) of this gene implicated in Kuhnt-Junius degeneration; diabetic retinopathy; and pre-eclampsia. Orthologous to human FLT1 (fms related receptor tyrosine kinase 1).


    Rat Flt1 molecular target information


    Molecular name:Flt1, Fms related receptor tyrosine kinase 1

    Alias:

    • FLT-1
    • FMS-like tyrosine kinase 1
    • FMS-related tyrosine kinase 1
    • Fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
    • LOC100911280
    • tyrosine-protein kinase receptor FLT
    • vascular endothelial growth factor receptor 1
    • vascular endothelial growth factor receptor 1-like
    • vascular endothelial growth factor/vascular permeability factor receptor
    • VEGFR-1

    Gene sequence:NCBI_Gene: 54251

    Protein sequence:


    Rat Flt1 target molecular function (prediction)


    Enables ATP binding activity; growth factor binding activity; and vascular endothelial growth factor-activated receptor activity. Involved in several processes, including liver regeneration; negative regulation of vascular endothelial growth factor production; and positive regulation of cell population proliferation. Located in extracellular space and plasma membrane. Used to study corneal neovascularization. Biomarker of breast cancer; diabetic retinopathy; liver cirrhosis; myocardial infarction; and vascular dementia. Human Ortholog(s) of this gene implicated in Kuhnt-Junius degeneration; diabetic retinopathy; and pre-eclampsia. Orthologous to human FLT1 (fms related receptor tyrosine kinase 1).