IL6R molecular target information overview
Overview of IL6R molecular targets
Interleukin 1 receptor antagonist (IL-1ra) is a member of the interleukin 1 (IL-1) cytokine family. It is secreted by a variety of cells including immune cells, epithelial cells and adipocytes and is a natural inhibitor of the pro-inflammatory effects of IL-1β. IL-ra is a mediator that can bind to the interleukin 1 receptor (IL-1R) on the cell surface inefficiently. IL-1R is also a receptor that binds to IL-1, so IL-1ra can prevent IL-1 from sending signals to cells. This protein inhibits the activity of IL-1α and IL-1β and regulates a variety of IL-1-related immune and inflammatory responses. IL-1RN gene polymorphisms are associated with an increased risk of osteoporotic fractures and gastric cancer. Mutations in this gene will lead to a rare disease, IL-1ra deficiency. Mutations in this gene are also associated with the risk of schizophrenia. It is used to treat rheumatoid arthritis.
Human IL6R Molecular Target Information
Molecular name: IL6R, interleukin 6 receptor
Alias:
- CD126
- CD126 antigen
- gp80
- HIES5
- IL-1Ra
- IL-6 receptor subunit alpha
- IL-6R
- IL-6R 1
- IL-6R subunit alpha
- IL-6R-1
- IL-6R-alpha
- IL-6RA
- IL6Q
- IL6QTL
- IL6RA
- IL6RQ
- interleukin 6 receptor alpha subunit
- interleukin-6 receptor subunit alpha
- membrane glycoprotein 80
- MGC104991
Gene sequence:NCBI_Gene: 3570
Protein sequence: UniProtKB: P08887
Human IL6R target molecular function (prediction)
Contributes to ciliary neurotrophic factor receptor activity; interleukin-6 receptor activity; and interleukin-6 receptor binding activity. Involved in several processes, including cytokine-mediated signaling pathway; positive regulation of cell population proliferation; and positive regulation of macromolecule metabolic process. Located in apical plasma membrane and extracellular space. Part of ciliary neurotrophic factor receptor complex and interleukin-6 receptor complex. Implicated in Alzheimer's disease; Huntington's disease; hyper IgE syndrome; obesity; and stomach cancer. Biomarker of several diseases, including Graves' disease; obesity; proliferative diabetic retinopathy; pulmonary tuberculosis; and sleep apnea.
Mouse Il6ra molecular target information
Molecular name: Il6ra, interleukin 6 receptor, alpha
Alias:
- CD126
- IL-6 receptor alpha chain
- IL-6R
- Il6r
- interleukin 6 receptor
Gene sequence:NCBI_Gene: 16194
Protein sequence:
Mouse Il6ra target molecular function (prediction)
Enables interleukin-6 binding activity and interleukin-6 receptor activity. Involved in T-helper 17 cell lineage commitment and interleukin-6-mediated signaling pathway. Located in cell surface. Part of interleukin-6 receptor complex. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; hemolymphoid system; and nervous system. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; hyper IgE syndrome; obesity; and stomach cancer. Orthologous to human IL6R (interleukin 6 receptor).
Rat Il6r molecular target information
Molecular name: Il6r, interleukin 6 receptor
Alias:
- IL-6 receptor subunit alpha
- IL-6R 1
- IL-6R subunit alpha
- IL-6R-alpha
- IL-6RA
- IL6R1
- Il6ra
- interleukin 6 receptor, alpha
- interleukin-6 receptor subunit alpha
Gene sequence:NCBI_Gene: 24499
Protein sequence:
Rat Il6r target molecular function (prediction)
Predicted to enable several functions, including cytokine binding activity; cytokine receptor activity; and protein homodimerization activity. Predicted to contribute to ciliary neurotrophic factor receptor activity and interleukin-6 receptor binding activity. Involved in several processes, including response to cAMP; response to gamma radiation; and response to lipopolysaccharide. neuropathy; and visual epilepsy. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; hyper IgE syndrome; obesity; and stomach cancer. Orthologous to human IL6R (interleukin 6 receptor).