ERBB2 molecular target information overview
Overview of ERBB2 molecular targets
ErbB2 is encoded by the ERBB2 gene in humans, also commonly referred to as the proto-oncogene human epidermal growth factor receptor 2 (HER2) or CD340. HER2 consists of three parts: an extracellular ligand binding domain, a transmembrane domain, and an intracellular domain. These domains can interact with a large number of signaling molecules, reflecting ligand-dependent and ligand-independent activities. Amplification or overexpression of this oncogene plays an important role in the development of certain adverse types of breast cancer. In recent years, this protein has become an important target for biological therapy in nearly 30% of breast cancer patients.
Human ERBB2 Molecular Target Information
Molecular name: ERBB2, erb-b2 receptor tyrosine kinase 2
Alias:
- c-erb B2/neu protein
- CD340
- HER-2
- HER-2/neu
- HER2
- herstatin
- human epidermal growth factor receptor 2
- metastatic lymph node gene 19 protein
- MLN 19
- NEU
- neuro/glioblastoma derived oncogene homolog
- neuroblastoma/glioblastoma derived oncogene homolog
- NGL
- p185erbB2
- proto-oncogene c-ErbB-2
- proto-oncogene Neu
- receptor tyrosine-protein kinase erbB-2
- TKR1
- tyrosine kinase-type cell surface receptor HER2
- v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
- v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)
- v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2
- v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
- VSCN2
Gene sequence:NCBI_Gene: 2064
Protein sequence:UniProtKB: P04626
Human ERBB2 target molecular function (prediction)
Enables several functions, including ErbB-3 class receptor binding activity; enzyme binding activity; and protein C-terminus binding activity. Contributes to growth factor binding activity. Involved in several processes, including positive of macromolecule biosynthetic process; protein phosphorylation; ERBB3:ERBB2 complex. Implicated in carcinoma (multiple); high grade glioma; reproductive organ cancer (multiple); and urinary bladder cancer. Biomarker of several diseases, including carcinoma (multiple); ductal carcinoma in situ; invasive lobular carcinoma; pre-eclampsia (multiple); and urinary system cancer (multiple).
Mouse Erbb2 molecular target information
Molecular name: Erbb2, erb-b2 receptor tyrosine kinase 2
Alias:
- avian erythroblastosis oncogene B 2
- c-erbB2
- c-neu
- Erbb-2
- ErbB-2
- HER-2
- HER2
- l11Jus8
- lethal, Chr 11, Justice 8
- mKIAA3023
- Neu
- Neu oncogene
Gene sequence:NCBI_Gene: 13866
Protein sequence:
Mouse Erbb2 target molecular function (prediction)
Predicted to enable several functions, including ErbB-3 class receptor binding activity; Hsp90 protein binding activity; and enzyme binding activity. Predicted to contribute to growth factor binding activity. Involved in positive of GTPase activity and positive regulation of protein phosphorylation. Acts upstream of or within several processes, including negative regulation of immature T cell proliferation in thymus; nervous system development; and neuromuscular junction development. vesicle; and myelin sheath. Is expressed in several structures, including adrenal gland; alimentary system; central nervous system; genitourinary system; and sensory organ. Used to study Hirschsprung's disease; breast cancer; and dilated cardiomyopathy. Human ortholog(s) of this gene implicated in carcinoma (multiple); high grade glioma; reproductive organ cancer (multiple); and urinary bladder cancer. Orthologous to human ERBB2 (erb-b2 receptor tyrosine kinase 2).
Rat Erbb2 molecular target information
Molecular name: Erbb2, erb-b2 receptor tyrosine kinase 2
Alias:
- Avian erythroblastosis viral (v-erb-B2) oncogene homologue 2 (neuro/glioblastoma derived oncogene homolog)
- C-erbB-2
- epidermal growth factor receptor-related protein
- HER2/neu
- LOC102552659
- neu
- NEU proto-oncogene
- p185erbB2
- p185neu
- proto-oncogene c-ErbB-2
- proto-oncogene NEU
- receptor tyrosine-protein kinase erbB-2
- receptor tyrosine-protein kinase erbB-2-like
- v-erb-b2 avian erythroblastic leukemia viral oncogene 2
- v-erb-b2 erythroblastic leukemia viral oncogene homolog 2
- v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
- v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
Gene sequence:NCBI_Gene: 24337
Protein sequence:
Rat Erbb2 target molecular function (prediction)
Enables Hsp90 protein binding activity; protein tyrosine kinase activity; and ubiquitin protein ligase binding activity. Involved in several processes, including animal organ development; nervous system development; and positive of intracellular signal transduction. Located in several cellular components, including basolateral plasma membrane; lateral loop; cardiomyopathy; high grade glioma; reproductive organ cancer (multiple); and urinary bladder cancer. Orthologous to human ERBB2 (erb-b2 receptor tyrosine kinase 2).