ICAM3 molecular target information overview
ICAM3 molecular targets review
Intercellular adhesion molecule 3 (ICAM-3), also known as CD50, is a member of the immunoglobulin superfamily that binds to the leukocyte integrins LFA-1 (CD11a/CD18) and αd/β2. ICAM-3 is expressed on leukocytes and epidermal Langerhans cells. ICAM-3 is a transmembrane glycoprotein expressed by leukocytes and is a counter-receptor for the lymphocyte function-associated antigen (LFA)-1 integrin. In addition to being an adhesion molecule for T cells to contact antigen-presenting cells, ICAM-3 can also regulate the affinity of LFA-1 for ICAM-1 and induce T cell activation and proliferation. ICAM-3 plays an important role in the initiation of immune responses by T cells and antigen-presenting cells. The CD50 molecule plays a role in the functional maturation of T lymphocytes and its expression increases during the maturation of T lymphocytes.
Human ICAM3 Molecular Target Information
Molecular name:ICAM3, intercellular adhesion molecule 3
Alias:
- CD50
- CDW50
- ICAM-3
- ICAM-R
- intercellular adhesion molecule-3
Gene sequence:NCBI_Gene: 3385
Protein sequence:UniProtKB: P32942
Human ICAM3 target molecular function (prediction)
Enables integrin binding activity. Predicted to be involved in cell adhesion. Located in extracellular exosome.