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CD44 molecular target information overview


  • Molecular name: CD44, CD44 molecule (Indian blood group)
  • Gene family: Blood group antigens; CD molecules; Proteoglycans
  • Alias: IN; MC56; Pgp1; CD44R; HCELL; CSPG8
  • Former names: MIC4; MDU2; MDU3
  • Alias: hematopoietic cell E- and L-selectin ligand; chondroitin sulfate proteoglycan 8; CD44 antigen (homing function and Indian blood group system)


    • CD44 molecular target review


    CD44 is a glycoprotein on the cell surface that participates in cell-cell interaction, cell adhesion and cell migration. CD44 is normally expressed in all blood cells (except platelets) and non-hematopoietic tissues, not in normal liver cells, but in bile duct epithelium. CD44 is abnormally expressed in multiple myeloma cells, most lymphomas, chronic lymphocytic leukemia, and tumor mast cells. CD44 is mainly involved in the activation of lymphocytes, the binding of matrix molecules such as hyaluronic acid and laminin in the extracellular matrix, and mediating the binding of lymphocytes to tall columnar endothelial cells in post-capillary venules, allowing lymphocytes to pass through the vascular wall and return to the lymphoid tissue.


    Human CD44 Molecular Target Information


    Molecular name: CD44, CD44 molecule (Indian blood group)


    Alias:

    • CD44 antigen
    • CDW44
    • cell surface glycoprotein CD44
    • chondroitin sulfate proteoglycan 8
    • CSPG8
    • ECMR-III
    • epican
    • extracellular matrix receptor III
    • GP90 lymphocyte homing/adhesion receptor
    • HCELL
    • hematopoietic cell E- and L-selectin ligand
    • heparan sulfate proteoglycan
    • Hermes antigen
    • homing function and Indian blood group system
    • HUTCH-I
    • hyaluronate receptor
    • IN
    • Indian blood group antigen
    • LHR
    • MC56
    • MDU2
    • MDU3
    • MGC10468
    • MIC4
    • MUTCH-I
    • Pgp1
    • phagocytic glycoprotein 1
    • soluble CD44

    Gene sequence:NCBI_Gene: 960

    Protein sequence:UniProtKB: P16070


    Human CD44 target molecule function (prediction)


    Enables hyaluronic acid binding activity. Contributes to cytokine receptor activity. Involved in several processes, including positive regulation of cell-cell adhesion; positive regulation of phosphorylation; and regulation of intracellular signal transduction. Located in several cellular components, including Golgi apparatus; apical plasma membrane; and lamellipodium membrane. Part of macrophage migration inhibitory factor receptor complex. Implicated in breast carcinoma (multiple); carcinoma (multiple); and prostate cancer. Biomarker of Krukenberg carcinoma; invasive ductal carcinoma; leiomyomatosis; lung adenocarcinoma; and urinary system cancer (multiple).


    Mouse Cd44 molecular target information


    Molecular name: Cd44, CD44 antigen


    Alias:

    • AU023126
    • AW121933
    • AW146109
    • expressed sequence AU023126
    • expressed sequence AW121933
    • expressed sequence AW146109
    • HERMES
    • Ly-24
    • lymphocyte antigen 24
    • Pgp-1
    • phagocyte glycoprotein 1


    Gene sequence:NCBI_Gene: 12505

    Protein sequence:


    Mouse Mouse Cd44 Target Molecular Function (Prediction)


    Acts upstream of or within several processes, including Wnt signaling pathway; morphogenesis of a branching epithelium; and wound healing involved in inflammatory response. Located in basolateral plasma membrane; external side of plasma membrane; and microvillus. Part of macrophage migration inhibitory factor receptor complex. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and limb. Human ortholog(s) of this gene implicated in breast carcinoma (multiple); carcinoma (multiple); and prostate cancer. Orthologous to human CD44 (CD44 molecule (Indian blood group)).


    Rat Cd44 molecular target information


    Molecular name: Cd44, CD44 molecule (Indian blood group)

    Alias:

    • CD44 antigen
    • CD44 antigen isoform d6-12
    • CD44 antigen isoform d6-13
    • CD44 antigen isoform d6-15
    • Cd44 molecule
    • CD44A
    • cell surface glycoprotein CD44 (hyaluronate binding protein)
    • ECMR-III
    • extracellular matrix receptor III
    • GP90 lymphocyte homing/adhesion receptor
    • hermes antigen
    • HUTCH-I
    • hyaluronate receptor
    • METAA
    • MGC124941
    • PGP-1
    • PGP-I
    • phagocytic glycoprotein 1
    • phagocytic glycoprotein I
    • RHAMM

    Gene sequence:NCBI_Gene: 25406

    Protein sequence:


    Rat Cd44 target molecular function (prediction)


    Enables epidermal growth factor receptor binding activity; phosphoprotein binding activity; and protein kinase binding activity. Involved in several processes, including blood vessel maturation; macrophage fusion; and positive of neutrophil apoptotic process. Located in regulation apical plasma membrane; basolateral plasma membrane; and nucleus. Part of protein-containing complex. Biomarker of borna disease and cholestasis. Human ortholog(s) of this gene implicated in breast carcinoma (multiple); carcinoma (multiple); and prostate cancer. Orthologous to human CD44 (CD44 molecule (Indian blood group)).