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CXCL11 Molecular Target Information Overview


  • Molecular name: CXCL11, CXC motif chemokine ligand 11
  • Gene family: Chemokine ligands
  • Alias: H174; b-R1; I-TAC; IP-9
  • Former name: SCYB9B; SCYB11
  • Alias: small inducible cytokine subfamily B (Cys-X-Cys), member 11; chemokine (CXC motif) ligand 11


    • CXCL11 molecular target review


    CXC motif chemokine 11 (CXCL11), also known as interferon-induced T cell alpha chemokine (I-TAC), is a small molecular weight cytokine in the CXC chemokine family. Its gene, like many other CXC chemokine family members, is located on human chromosome 4. It is highly expressed in peripheral blood leukocytes, pancreas and liver, moderately expressed in thymus, spleen and lung, and lowly expressed in small intestine, placenta and prostate tissues. IFN-γ and IFN-β can strongly induce the expression of CXCL11 gene, while IFN-α has a weak induction effect on it. CXCL11 acts on target cells by interacting with the cell surface chemokine receptor CXCR3. CXCL11 chemotactic activated T cells. CXCL11 has an angiogenesis-inhibiting effect and is involved in allergic contact dermatitis, atherosclerosis, mycosis fungoides (a T-cell lymphoma), and immune-mediated central nervous system disorders such as multiple sclerosis.


    Human CXCL11 Molecular Target Information


    Molecular name: CXCL11, CXC motif chemokine ligand 11


    Alias:

    • b-R1
    • beta-R1
    • CXC motif chemokine 11
    • chemokine (CXC motif) ligand 11
    • H174
    • I-TAC
    • interferon gamma-inducible protein 9
    • interferon-inducible T-cell alpha chemoattractant
    • IP-9
    • IP9
    • MGC102770
    • SCYB11
    • SCYB9B
    • small inducible cytokine B11
    • small inducible cytokine subfamily B (Cys-X-Cys), member 11
    • small inducible cytokine subfamily B (Cys-X-Cys), member 9B
    • small-inducible cytokine B11

    Gene sequence:NCBI_Gene: 6373

    Protein sequence: UniProtKB: O14625


    Human CXCL11 target molecular function (prediction)


    Enables CXCR3 chemokine receptor binding activity; chemokine activity; and heparin binding activity. Involved in several processes, including T cell chemotaxis; chemokine-mediated signaling pathway; and positive of release of sequestered calcium ion into cytosol. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Biomarker of bronchiolitis obliterans; chronic obstructive pulmonary disease; and pulmonary sarcoidosis.


    Mouse Cxcl11 molecular target information


    Molecular name: Cxcl11, chemokine (CXC motif) ligand 11


    Alias:

    • b-R1
    • betaR1
    • H174
    • I-TAC
    • IP9
    • ITAC
    • Scyb11
    • SCYB9B
    • small inducible cytokine subfamily B (Cys-X-Cys), member 11


    Gene sequence:NCBI_Gene: 56066

    Protein sequence:


    Mouse Cxcl11 target molecular function (prediction)


    Predicted to enable CXCR chemokine receptor binding activity and chemokine activity. Predicted to be involved in several processes, including cellular response to lipopolysaccharide; chemokine-mediated signaling pathway; and neutrophil chemotaxis. Predicted to be active in extracellular space. Is expressed in head; nasal cavity epithelium; palatal shelf epithelium; palatal shelf mesenchyme; and testis. (CXC motif chemokine ligand 11).


    Rat Cxcl11 molecular target information


    Molecular name: Cxcl11, CXC motif chemokine ligand 11

    Alias:

    • CXC motif chemokine 11
    • chemokine (CXC motif) ligand 11
    • SCYB11

    Gene sequence:NCBI_Gene: 305236

    Protein sequence:UniProtKB: Q7TNL0


    Rat Cxcl11 target molecular function (prediction)


    Enables chemokine activity. Involved in immune response. Predicted to be integral component of membrane. Predicted to be active in extracellular space. Orthologous to human CXCL11 (CXC motif chemokine ligand 11).