Blog

CD36 molecular target information overview


  • Molecular name: CD36, CD36 molecule
  • Gene family: CD molecules; Scavenger receptors
  • Alias: SCARB3; GPIV; FAT; GP4; GP3B
  • Alias: CD36 antigen (collagen type I receptor, thrombospondin receptor); CD36 molecule (thrombospondin receptor)


    • CD36 molecular target review


    CD36 is an 85kDa glycoprotein also known as GPIIIb or GPI, and is a receptor for extracellular matrix proteins such as collagen and thrombospondin. The CD36 antigen is expressed on monocytes, platelets, endothelial cells, and some human tumor cell lines, but not on lymphocytes and granulocytes, and is an early marker of erythroid differentiation. CD36 is known to mediate the adhesion of Plasmodium falciparum. CD36 antibodies can induce cell degranulation, release of ATP and 5-hydroxytryptamine, increase [Ca2+]ι, and tyrosine phosphorylation of 130k Da substrate proteins. CD36 can bind to thrombospondin, long-chain fatty acids, oxidized LDL, collagen types I, IV, and V, and apoptotic cells.


    Human CD36 Molecular Target Information


    Molecular name: CD36, CD36 molecule


    Alias:

    • BDPLT10
    • CD36 antigen (collagen type I receptor, thrombospondin receptor)
    • CD36 molecule (thrombospondin receptor)
    • CHDS7
    • cluster acid determinant 36
    • FAT
    • fatty translocase
    • glycoprotein IIIb
    • GP3B
    • GP4
    • GPIIIB
    • GPIV
    • leukocyte differentiation antigen CD36
    • PAS IV
    • PAS-4 protein
    • PASIV
    • platelet glycoprotein 4
    • platelet glycoprotein IV
    • SCARB3
    • scavenger receptor class B, member 3

    Gene sequence:NCBI_Gene: 948

    Protein sequence:UniProtKB: P16671


    Human CD36 target molecule function (prediction)


    Enables several functions, including amyloid-beta binding activity; fatty acid transmembrane transporter activity; and low-density lipoprotein particle binding activity. Involved in several processes, including amyloid-beta clearance by cellular catabolic process; lipid transport; and second-messenger-mediated signaling. Located in several cellular components, including Golgi apparatus; cell surface; and membrane raft. Part of receptor complex. Implicated in several diseases, including blood platelet disease (multiple); hemolytic-uremic syndrome; osteoarthritis; pulmonary tuberculosis; and type 2 diabetes mellitus. Biomarker of several diseases, including autoimmune disease (multiple); myeloid neoplasm (multiple); myositis (multiple); rheumatic heart disease; and sickle cell anemia.


    Mouse Cd36 molecular target information


    Molecular name: Cd36, CD36 molecule


    Alias:

    • FAT
    • fatty acid translocase
    • Scarb3


    Gene sequence:NCBI_Gene: 12491

    Protein sequence:


    Mouse Mouse Cd36 Target Molecular Function (Prediction)


    Is expressed in several cellular components, including brush border membrane; external side of plasma membrane; and membrane raft. Is expressed in several cellular components, including brush border membrane; external side of plasma membrane; and membrane raft. structures, including Meckel's cartilage; axial skeleton; bone; hindlimb; and telencephalon. Used to study platelet-type bleeding disorder 10. Human ortholog(s) of this gene implicated in several diseases, including blood platelet disease (multiple); hemolytic-uremic syndrome; osteoarthritis; pulmonary tuberculosis;


    Rat Cd36 molecular target information


    Molecular name: Cd36, CD36 molecule

    Alias:

    • adipocyte membrane protein
    • CD36 antigen
    • CD36 antigen (collagen type I receptor, thrombospondin receptor)
    • Cd36 antigen-like
    • CD36 molecule (thrombospondin receptor)
    • collagen type I receptor thrombospondin receptor
    • Fat
    • fatty acid translocase
    • fatty acid transport protein
    • glycoprotein IIIb
    • GPIIIB
    • GPIV
    • LOC499984
    • MGC108510
    • MGC91634
    • PAS IV
    • PAS-4
    • platelet glycoprotein 4
    • platelet glycoprotein IV
    • RGD1562323
    • similar to fatty acid translocase/CD36

    Gene sequence:NCBI_Gene: 29184

    Protein sequence:


    Rat Cd36 target molecular function (prediction)


    Enables several functions, including oleic acid binding activity; scavenger receptor activity; and thrombospondin receptor activity. Involved in several processes, including fatty acid metabolic process; positive regulation of macromolecule metabolic process; and response to peptide hormone. Located in several cellular components, including brush border membrane; caveola; and sarcolemma. Part of protein-containing complex. Used to study interstitial lung disease (multiple); macular degeneration; myocardial infarction; obesity; and polycystic ovary syndrome. Biomarker of artery disease (multiple); hypertrophic cardiomyopathy; nephrosis; obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including blood platelet disease (multiple); hemolytic-uremic syndrome; osteoarthritis; pulmonary tuberculosis; and type 2 diabetes mellitus. Orthologous to human CD36 (CD36 molecule).