FGF7 molecular target information overview
Overview of FGF7 molecular targets
Keratinocyte growth factor (KGF), also known as fibroblast growth factor 7 (FGF-7), is a growth factor in the epithelialization stage of wound healing. During this stage, keratinocytes cover the wound and form epithelial cells. Fibroblasts, embryonic mesenchymal cells, and smooth muscle cells can express KGF. KGF is a small signaling molecule that needs to bind to fibroblast growth factor receptor 2b (FGFR2b) to produce a signal. Studies have shown that KGF is a paracrine effector of many different epithelial cell types. KGF can not only induce cell proliferation, but also promote epithelial cell differentiation. Cytokines such as IL-1α, IL-1β, and IL-6 not only activate local connective tissue cells, remove foreign bodies and reshape tissues, but also stimulate the production of KGF in fibroblasts, promoting re-epithelialization and wound healing.
Human FGF7 molecular target information
Molecular name: FGF7, fibroblast growth factor 7
Alias:
- FGF-7
- HBGF-7
- heparin-binding growth factor 7
- keratinocyte growth factor
- KGF
Gene sequence:NCBI_Gene: 2252
Protein sequence:UniProtKB: P21781
Human FGF7 target molecular function (prediction)
Enables chemoattractant activity. Involved in several processes, including positive regulation of keratinocyte migration; positive regulation of keratinocyte proliferation; and protein localization to cell surface. Acts upstream of or within fibroblast growth factor receptor signaling pathway and positive regulation of epithelial cell proliferation involved in lung morphogenesis. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and extracellular space. Biomarker of several diseases, including inflammatory bowel disease (multiple); leiomyoma; prostatic hypertrophy; reproductive organ cancer (multiple); and severe acute respiratory syndrome.
Mouse Fgf7 molecular target information
Molecular name: Fgf7, fibroblast growth factor 7
Also known as:
- Keratinocyte growth factor
- Kgf
Gene sequence:NCBI_Gene: 14178
Protein sequence:
Mouse Fgf7 target molecular function (prediction)
Predicted to enable heparin binding activity; receptor ligand activity; and type 2 fibroblast growth factor receptor binding activity. Involved in positive regulation of transcription, DNA-templated. Acts upstream of or within morphogenesis of an epithelium; positive regulation of epithelial cell proliferation; and regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling. Located in Golgi apparatus and extracellular region. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; genitourinary system; and integumental system. Orthologous to human FGF7 (fibroblast growth factor 7).
Rat Fgf7 molecular target information
Molecular name: Fgf7, fibroblast growth factor 7
Alias:
- FGF-7
- Fgf5b
- fibroblast growth factor 5b
- HBGF-7
- heparin-binding growth factor 7
- keratinocyte growth factor
- Keratinocyte Growth Factor Fgf-7
- Kgf
- KGF/FGF7
Gene sequence:NCBI_Gene: 29348
Protein sequence:
Rat Fgf7 target molecular function (prediction)
Enables growth factor activity; heparin binding activity; and type 2 fibroblast growth factor receptor binding activity. Involved in several processes, including ovarian follicle development; phosphatidylcholine biosynthetic process; and surfactant homeostasis. Located in extracellular space. Orthologous to human FGF7 (fibroblast growth factor 7).