SOS1 molecular target information overview
Overview of SOS1 molecular targets
Hepatocyte growth factor (HGF), also known as scatter factor, hepatocyte poi- topoietin A, and mammary growth factor, is a pleiotropic glycoprotein that regulates growth and migration of multiple cell types. HGF is secreted as a full-length inactive polypeptide and then cleaved by serine proteases into an active heterodimeric molecule of a 60 kDa N-terminal α chain and a 30 kDa C-terminal β chain. HGF is expressed by fibroblasts, adipocytes, smooth muscle cells, and endothelial cells. Serum levels of HGF are elevated in a variety of pathologies, including liver injury, acute renal failure, myocardial infarction, type 1 diabetes, obesity, and cancer, as well as in the joint fluid of patients with rheumatoid arthritis.
Human SOS1 Molecular Target Information
Molecular name: SOS1, SOS Ras/Rac guanine nucleotide exchange factor 1
Alias:
- GF1
- GGF1
- GINGF
- gingival fibromatosis, hereditary, 1
- guanine nucleotide exchange factor
- HGF
- NS4
- son of sevenless homolog 1
- SOS-1
Gene sequence:NCBI_Gene: 6654
Protein sequence:UniProtKB: Q07889
Human SOS1 target molecular function (prediction)
Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in axon guidance; cell surface receptor signaling pathway; and leukocyte migration. Predicted to act upstream of or within several processes, including animal organ development; regulation of T cell activation; and transmembrane receptor protein tyrosine kinase signaling pathway. Located in cytoplasm. Implicated in Noonan syndrome; Noonan syndrome 4; and gingival fibromatosis. Biomarker of cervical cancer and prostate cancer.
Mouse Sos1 molecular target information
Molecular name: Sos1, SOS Ras/Rac guanine nucleotide exchange factor 1
Alias:
- AI573415
- expressed sequence AI573415
- Sfpd
- Sftp4
- SP-D
- surfactant-associated protein 4
Gene sequence:NCBI_Gene: 20662
Protein sequence:
Mouse Sos1 target molecular function (prediction)
Enables identical protein binding activity. Predicted to be involved in several processes, including induction of bacterial agglutination; negative regulation of interleukin-2 production; and regulation of phagocytosis. Predicted to act upstream of or within innate immune response and respiratory gaseous exchange by respiratory system. Located in cytoplasm. syncytial virus infectious disease; and rhinitis. Orthologous to human SFTPD (surfactant protein D).
Rat Sos1 molecular target information
Molecular name: Sos1, SOS Ras/Rac guanine nucleotide exchange factor 1
Son of sevenless homolog 1 (Drosophila)
Gene sequence:NCBI_Gene: 313845
Protein sequence:
Rat Sos1 target molecular function (prediction)
Enables SH3 domain binding activity. Involved in Ras protein signal transduction; neurotrophin TRK receptor signaling pathway; and positive regulation of signal transduction. Located in neuronal cell body; plasma membrane; and postsynaptic density. Human ortholog(s) of this gene implicated in Noonan syndrome; Noonan syndrome 4; and gingival fibromatosis. Orthologous to human SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1).