IGF1R molecular target information overview
IGF1R molecular targets review
The insulin-like growth factor 1 receptor (IGF-1R) is located on the surface of human cells. It is a transmembrane receptor activated by the hormone insulin-like growth factor 1 (IGF-1) and another related hormone insulin-like growth factor 2 (IGF-2). It belongs to a large class of tyrosine kinase receptors. IGF-1R mediates the function of IGF-1, a polypeptide protein hormone similar to insulin in molecular structure. It plays an important role in growth and development and adult anabolism, and can cause excessive proliferation of skeletal muscle or other target tissues. Mice lacking IGF-1R will die in the late stages of development, showing a sharp drop in weight, proving that the receptor has a strong promoting effect on growth. Studies have shown that IGF-1R is associated with some cancers, including breast cancer, prostate cancer and lung cancer.
Human IGF1R Molecular Target Information
Molecular name:IGF1R, insulin like growth factor 1 receptor
Alias:
- CD221
- IGF-I receptor
- IGFIR
- IGFR
- insulin-like growth factor 1 receptor
- insulin-like growth factor I receptor
- JTK13
- MGC142170
- MGC142172
- MGC18216
- soluble IGF1R variant 1
- soluble IGF1R variant 2
Gene sequence:NCBI_Gene: 3480
Protein sequence: UniProtKB: P08069
Human IGF1R target molecular function (prediction)
Enables several functions, including insulin binding activity; insulin receptor binding activity; and insulin receptor substrate binding activity. Involved in several processes, including cellular response to amyloid-beta; insulin-like growth factor receptor signaling pathway; and regulation of MAPK cascade. Acts upstream of or within peptidyl-tyrosine autophosphorylation. Located in cellular intracellular membrane-bounded organelle and membrane. Part of alphav-beta3 integrin-IGF-1-IGF1R complex; protein kinase complex; and receptor complex. Implicated in several diseases, including IgA glomerulonephritis; dementia (multiple); kidney cancer (multiple); liver disease (multiple); and nervous system cancer (multiple). Biomarker of several diseases, including Kuhnt-Junius degeneration; autoimmune disease (multiple); endocrine gland cancer (multiple); neurodegenerative disease (multiple);
Mouse Igf1r molecular target information
Molecular name:Igf1r, insulin-like growth factor I receptor
Alias:
- A330103N21Rik
- CD221
- hydrops fetalis
- hyft
- IGF-1R
- line 186
- RIKEN cDNA A330103N21 gene
Gene sequence:NCBI_Gene: 16001
Protein sequence:
Mouse Igf1r target molecular function (prediction)
Acts upstream of or within several processes, including gland development; peptidyl-tyrosine autophosphorylation; and regulation of intracellular signal transduction. Located in T-tubule. Is integral component of membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and lung. Human ortholog(s) of this gene implicated in several diseases, including dementia (multiple); kidney cancer (multiple); liver disease (multiple); nervous system cancer (multiple); and neurodegenerative disease (multiple). Orthologous to human IGF1R (insulin like growth factor 1 receptor).
Rat Igf1r molecular target information
Molecular name:Igf1r, insulin-like growth factor 1 receptor
Alias:
- IGF-1 receptor
- IGF-I receptor
- IGFIRC
- Igfr1
- insulin-like growth factor I receptor
- JTK13
- type-I IGF receptor
Gene sequence:NCBI_Gene: 25718
Protein sequence:
Rat Igf1r target molecular function (prediction)
Enables G-protein alpha-subunit binding activity; insulin receptor substrate binding activity; and insulin-like growth factor-activated receptor activity. Involved in several processes, including cellular response to hormone stimulus; negative regulation of apoptotic process; and nervous system development. Located in several cellular components, including T-tubule; caveola; and neuronal cell body. Used to study Alzheimer's disease; Parkinson's disease; and prostate adenocarcinoma. Biomarker of several diseases, including alcoholic neuropathy; artery disease (multiple); cryptorchidism; diabetes mellitus (multiple); and neurodegenerative disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; dementia (multiple); kidney cancer (multiple); liver disease (multiple); and nervous system cancer (multiple). Orthologous to human IGF1R (insulin like growth factor 1 receptor).