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BMP4 molecular target information overview


  • Molecular name: BMP4, bone morphogenetic protein 4
  • Gene family: Bone morphogenetic proteins
  • Former name: BMP2B


    • Overview of BMP4 molecular targets


    BMPs are secreted signaling molecules that comprise a subfamily of the TGF-β superfamily and were originally identified as regulators of cartilage and bone formation. In general, BMPs are associated with embryogenesis and morphogenesis of various tissues and organs. BMP-2, BMP-4, and BMP-7, play a role in the specification of hematopoietic tissues of the mesodermal germ layer. They regulate the proliferation and differentiation of highly purified primitive human hematopoietic cells from adult and neonatal sources. BMP-4, also known as bone morphogenetic protein 4, forms disulfide-linked homodimers. BMP-4 has also been shown to be involved in the differentiation of sympathetic neurons. It enhances the formation of adrenergic sympathetic neurons in neuroc cell cultures.


    Human BMP4 Molecular Target Information


    Molecular name: BMP4, bone morphogenetic protein 4


    Alias:

    • BMP-2B
    • BMP-4
    • BMP2B
    • BMP2B1
    • bone morphogenetic protein 2B
    • bone morphogenetic protein 4 preproprotein
    • MCOPS6
    • OFC11
    • ZYME

    Gene sequence:NCBI_Gene: 652

    Protein sequence: UniProtKB: P12644


    Human BMP4 target molecular function (prediction)


    Enables BMP receptor binding activity; co-receptor binding activity; and receptor ligand activity. Involved in several processes, including animal organ development; negative regulation of cell population proliferation; and transmembrane receptor protein serine/threonine kinase signaling pathway. Acts upstream of or within several processes, including positive regulation of osteoblast differentiation; regulation of transcription by RNA polymerase II; cleft lip; orofacial cleft 11; ossification of the posterior longitudinal ligament of spine; and otosclerosis. Biomarker of several diseases, including Barrett's esophagus; eye disease (multiple); myositis ossificans; progressive osseous heteroplasia; and prolactinoma.


    Mouse Bmp4 molecular target information


    Molecular name: Bmp4, bone morphogenetic protein 4


    Alias:

    • Bmp-4
    • Bmp2b
    • Bmp2b-1
    • Bmp2b1
    • bone morphogenetic protein 2b
    • bone morphogenetic protein 2b 1


    Gene sequence:NCBI_Gene: 12159

    Protein sequence:


    Mouse Bmp4 target molecular function (prediction)


    Acts upstream of or within several processes, including animal organ development; embryonic morphogenesis; and regulation of animal organ morphogenesis. Located in extracellular space. Is expressed in several structures, including alimentary system; embryo ectoderm; embryo mesenchyme; genitourinary system; and sensory organ. Used to study Axenfeld-Rieger syndrome type 3; atrioventricular septal defect; cleft palate-lateral synechia syndrome; fibrodysplasia ossificans progressiva; and urinary system disease. Human ortholog(s) of this gene implicated in several diseases, including CAKUT (multiple); cleft lip; orofacial cleft 11; ossification of the posterior longitudinal ligament of spine; and otosclerosis. Orthologous to human BMP4 (bone morphogenetic protein 4).


    Rat Bmp4 molecular target information


    Molecular name: Bmp4, bone morphogenetic protein 4

    Alias:

    • BMP-2B
    • BMP-4
    • BOMPR4A
    • bone morphogenetic protein 2B

    Gene sequence:NCBI_Gene: 25296

    Protein sequence:


    Rat Bmp4 target molecular function (prediction)


    Enables growth factor activity and identical protein binding activity. Involved in several processes, including animal organ development; positive regulation of calcium ion transport; and positive regulation of cell differentiation. Acts upstream of or within positive regulation of ossification and positive regulation of transcription by RNA polymerase II. Located in cytoplasm; extracellular space; and vesicle. Biomarker of Barrett's esophagus; congenital diaphragmatic hernia; epilepsy; peptic esophagitis; and prolactinoma. Human ortholog(s) of this gene implicated in several diseases, including CAKUT (multiple); cleft lip; orofacial cleft 11; ossification of the posterior longitudinal ligament of spine; and otosclerosis. Orthologous to human BMP4 (bone morphogenetic protein 4).