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IL27 molecular target information overview


  • Molecular name: IL27, interleukin 27
  • Gene family: Interleukins
  • Other names: IL-27; p28; IL27p28; IL-27A; IL27A; MGC71873
  • Former name: IL30
  • Alias: interleukin 30


    • Overview of IL27 molecular targets


    Interleukin 27 (IL-27) is a member of the IL-12 family and is a heterodimeric protein composed of two subunits, Epstein-Barr virus (EBV)-induced gene 3 (EBI3, also known as IL-27B) and IL-27p28 (known as IL-30). IL-27 is produced by antigen-presenting cells and plays an important role in regulating the activity of B and T lymphocytes. IL-27 exerts its effects by interacting with a specific cell surface receptor complex composed of two proteins, IL-27R and gp130. IL-27 has both pro-inflammatory and anti-inflammatory properties. In response to infection, IL-27 induces monocytes and mast cells to secrete pro-inflammatory cytokines, which induces the proliferation of naive CD4+T cells and causes Th1 cell responses. IL-27 also promotes the effector function of NK cells and CD8+T cells. As an anti-inflammatory immunomodulator, IL-27 can inhibit Th1 or Th2 responses, limiting the intensity and duration of adaptive immune responses. Recent studies have shown that IL-27 has promising antitumor activity and has been reported to be actively involved in the induction of inflammation in rheumatoid arthritis.


    Human IL27 Molecular Target Information


    Molecular name: IL27, interleukin 27


    Alias:

    • IL-27
    • IL-27 p28 subunit
    • IL-27 subunit alpha
    • IL-27-A
    • IL-27A
    • IL27-A
    • IL27A
    • IL27p28
    • IL30
    • interleukin 30
    • interleukin-27 subunit alpha
    • interleukin-30
    • MGC71873
    • p28

    Gene sequence:NCBI_Gene: 246778

    Protein sequence:UniProtKB: Q8NEV9


    Human IL27 target molecular function (prediction)


    Predicted to enable interleukin-27 receptor binding activity. Involved in positive regulation of interferon-gamma production and regulation of T-helper 1 cell differentiation. Predicted to be located in cytosol; endoplasmic reticulum lumen; and extracellular region. Predicted to be active in extracellular space. Implicated in asthma; chronic obstructive pulmonary disease; Henoch-Schoenlein purpura; hepatitis B; infectious mononucleosis; peptic ulcer disease (multiple); and tuberculosis (multiple).


    Mouse Il27 molecular target information


    Molecular name: Il27, interleukin 27


    Alias:

    • IL-27
    • IL-27p28
    • Il30
    • interleukin 30
    • p28


    Gene sequence:NCBI_Gene: 246779

    Protein sequence:


    Mouse Il27 target molecular function (prediction)


    Enables interleukin-27 receptor binding activity. Acts upstream of or within positive regulation of defense response to virus by host and regulation of T cell proliferation. Located in extracellular space. Is expressed in decidua; embryo; and extraembryonic component. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; and pulmonary tuberculosis. Orthologous to human IL27 (interleukin 27).


    Rat Il27 molecular target information


    Molecular name: Il27, interleukin 27

    Alias:

    • interleukin-27 subunit alpha
    • LOC365368
    • RGD1561420
    • similar to IL-27 p28 subunit

    Gene sequence:NCBI_Gene: 365368

    Protein sequence:UniProtKB: D3ZPW3


    Rat Il27 target molecular function (prediction)


    Predicted to enable interleukin-27 receptor binding activity. Involved in response to bacterium. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; and pulmonary tuberculosis. Orthologous to human IL27 (interleukin 27).