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TGFB2 molecular target information overview


  • Molecular name: TGFB2, transforming growth factor beta 2
  • Gene family: Transforming growth factor beta family
  • Alias: prepro-transforming growth factor beta-2; transforming growth factor, beta 2


    • Overview of TGFB2 molecular targets


    The precursor protein of transforming growth factor β2 (TGF-β2) consists of a 19-amino acid signal peptide, a 283-amino acid pro-region, and a 112-amino acid mature region. The homology of the mature region of human TGF-β2 to human TGF-β1 and TGF-β3 is 71% and 80%, respectively, and 97% to mouse TGF-β2. It can be expressed by various cells, including osteoclasts, thymic epithelial cells, keratinocytes, hepatocytes, chief cells and satellite cells of the stomach, etc. TGF-β2 has significant cross-species biological activity, such as human TGF-β2 is active on mouse cells, while porcine TGF-β2 is active on rabbit cells, etc. TGF-β2 has four basic activities: it is a growth inhibitory factor for most types of cells; it can enhance the deposition of extracellular matrix; it has an immunosuppressive effect, inhibiting the expression of IL-12 and CD40L by antigen-presenting cells and upregulating IL-10 secretion; it is expressed in discrete areas during embryonic development, such as the epithelium, myocardium, cartilage and bones of the hands and feet, and the nervous system, suggesting that it has specific functions.


    Human TGFB2 Molecular Target Information


    Molecular name:TGFB2, transforming growth factor beta 2


    Alias:

    • BSC-1 cell growth inhibitor
    • cetermin
    • G-TSF
    • glioblastoma-derived T-cell suppressor factor
    • LDS4
    • MGC116892
    • polyergin
    • prepro-transforming growth factor beta-2
    • TGF-beta-2
    • TGF-beta2
    • transforming growth factor beta-2
    • transforming growth factor beta-2 proprotein
    • transforming growth factor, beta 2

    Gene sequence:NCBI_Gene: 7042

    Protein sequence:UniProtKB: P61812


    Human TGFB2 target molecular function (prediction)


    Enables amyloid-beta binding activity; protein homodimerization activity; and transforming growth factor beta receptor binding activity. Involved in several processes, including animal organ development; cell surface receptor signaling pathway; and positive of signal transduction. Located in collagen-containing extracellular matrix and extracellular space regulation. Implicated in Loeys-Dietz syndrome 4 and colorectal cancer. Biomarker of colon carcinoma; colorectal cancer; and liver cirrhosis.


    Mouse Tgfb2 molecular target information


    Molecular name:Tgfb2, transforming growth factor, beta 2


    Alias:

    • BB105277
    • expressed sequence BB105277
    • Tgf-beta2
    • Tgfb-2


    Gene sequence:NCBI_Gene: 21808

    Protein sequence:


    Mouse Tgfb2 target molecular function (prediction)


    Predicted to enable several functions, including amyloid-beta binding activity; protein homodimerization activity; and transforming growth factor beta receptor binding activity. Involved in several processes, including animal organ development; regulation of epithelial to mesenchymal transition involved in endocardial cushion formation; and tube morphogenesis. Acts upstream of or within several processes, including animal organ development; neuron differentiation; neuronal cell body. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Used to study Loeys-Dietz syndrome. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 4 and colorectal cancer. Orthologous to human TGFB2 (transforming growth factor beta 2).


    Rat Tgfb2 molecular target information


    Molecular name:Tgfb2, transforming growth factor, beta 2

    Alias:

    • TGF beta 2 protein
    • TGF-B2
    • TGF-beta-2
    • transforming growth factor beta-2
    • transforming growth factor beta-2 proprotein

    Gene sequence:NCBI_Gene: 81809

    Protein sequence:


    Rat Tgfb2 target molecular function (prediction)


    Enables identical protein binding activity and protein N-terminus binding activity. Involved in several processes, including animal organ development; negative regulation of release of sequestered calcium ion into cytosol; and regulation of apoptotic process. Located in several cellular components, including basement membrane; secretory granule; and trans-Golgi network. Biomarker of diabetic neuropathy; myocardial infarction; and osteochondrodysplasia. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 4 and colorectal cancer. Orthologous to human TGFB2 (transforming growth factor beta 2).