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NCAM1 molecular target information overview


  • Molecular name:NCAM1, neural cell adhesion molecule 1
  • Gene family:CD molecules; Fibronectin type III domain containing; I-set domain containing; Ig-like cell adhesion molecule family
  • Alias: NCAM; CD56


    • Overview of NCAM1 molecular targets


    CD56, also known as neural cell adhesion molecule (NCAM), Leu-19 or NKH1, is a transmembrane glycoprotein with a molecular weight of 140 kD. CD56 is expressed in neurons and plays a role in the homogeneous adhesion of nerve cells. In the hematopoietic system, it is expressed in NK and NKT cells and plays a role in cell adhesion.


    Human NCAM1 Molecular Target Information


    Molecular name:NCAM1, neural cell adhesion molecule 1


    Alias:

    • antigen recognized by monoclonal antibody 5.1H11
    • CD56
    • MSK39
    • N-CAM-1
    • NCAM
    • NCAM-1
    • neural cell adhesion molecule, NCAM

    Gene sequence:NCBI_Gene: 4684

    Protein sequence:UniProtKB: P13591


    Human NCAM1 target molecular function (prediction)


    Predicted to enable virus receptor activity. Predicted to be involved in commissaural neuron axon guidance; modulation of chemical synaptic transmission; and regulation of semaphorin-plexin signaling pathway. Predicted to act upstream of or within several processes, including homotypic cell-cell adhesion; positive regulation of calcium-mediated signaling; and regulation of exocyst assembly. Located in cytosol and external side of plasma membrane. Implicated in bipolar disorder; middle cerebral artery infarction and pancreatic cancer. Biomarker of several diseases, including acute promyelocytic leukemia; brain glioblastoma multiforme; cholangiocarcinoma; insulinoma; and ovarian serous carcinoma.


    Mouse Ncam1 molecular target information


    Molecular name:Ncam1, neural cell adhesion molecule 1


    Alias:

    • CD56
    • E-NCAM
    • NCAM
    • NCAM-1
    • NCAM-120
    • NCAM-140
    • NCAM-180


    Gene sequence:NCBI_Gene: 17967

    Protein sequence:


    Mouse Ncam1 target molecular function (prediction)


    Predicted to enable LRR domain binding activity and phosphatase binding activity. Involved in commissaural neuron axon guidance and regulation of semaphorin-plexin signaling pathway. Acts upstream of or within several processes, including homotypic cell-cell adhesion; positive regulation of calcium-mediated signaling; and regulation of exocyst assembly. Located in several cellular components, including external side of plasma membrane; growth cone; and neuronal cell body. Is expressed in several structures, including embryo mesenchyme; nervous system; sensory organ; skin; and urinary system. Human ortholog(s) of this gene implicated in bipolar disorder; middle cerebral artery infarction; and pancreatic cancer. Orthologous to human NCAM1 (neural cell adhesion molecule 1).


    Rat Ncam1 molecular target information


    Molecular name:Ncam1, neural cell adhesion molecule 1

    Alias:

    • Cd56
    • Cell adhesion molecule neural (CD56)
    • cell adhesion molecule, neural (CD56)
    • MGC124601
    • N-CAM
    • N-CAM-1
    • Ncam
    • NCAM-1
    • NCAM-C
    • NCAMC
    • neural cell adhesion molecule

    Gene sequence:NCBI_Gene: 24586

    Protein sequence:


    Rat Ncam1 target molecular function (prediction)


    Enables enzyme binding activity. Involved in cellular response to hypoxia; flagellated sperm motility; and spermatogenesis. Located in cytoplasm. Orthologous to several human genes including MST1 (macrophage stimulating 1).