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VWF molecular target information overview


  • Molecular name: VWF, von Willebrand factor
  • Gene family: Receptor ligands
  • Former name: F8VWF
  • Alias: Factor VIII related antigen


    • Overview of VWF molecular targets


    Von Willebrand factor (vWF) is a multimeric glycoprotein present in plasma, with very large vWF produced in the endothelium (Weibel-Palade bodies), megakaryocytes (platelet α-granules), and subendothelial connective tissue. vWF multimers are very large (greater than 20,000 kDa) and consist of more than 80 subunits of 250 kDa each. The main function of vWF is to bind to other proteins, particularly factor VIII, which plays an important role in platelet adhesion to wound sites, and it also plays an important role in the coagulation process. Therefore, the absence or dysfunction of vWF (von Willebrand disease) will lead to a bleeding tendency, which is most obvious in tissues with high blood flow in narrow vessels. Monitoring the level of vWF in serum can provide more detailed insights into some pathological conditions such as thrombotic thrombocytopenic purpura, Hyde syndrome, and possibly hemolytic uremic syndrome.


    Human VWF Molecular Target Information


    Molecular name: VWF, von Willebrand factor


    Alias:

    • coagulation factor VIII VWF
    • F8VWF
    • VWD

    Gene sequence:NCBI_Gene: 7450

    Protein sequence:UniProtKB: P04275


    Human VWF target molecular function (prediction)


    Enables several functions, including chaperone binding activity; identical protein binding activity; and integrin binding activity. Involved in cell-substrate adhesion; platelet activation; and positive regulation of intracellular signal transduction. Located in several cellular components, including Weibel-Palade body; collagen-containing extracellular matrix; and endoplasmic reticulum. Implicated in several diseases, including Behcet's disease; Bernard-Soulier syndrome; end stage renal disease; essential thrombocythemia; and von Willebrand's disease (multiple). Biomarker of several diseases, including end stage renal disease; familial combined hyperlipidemia; obesity; osteonecrosis; and von Willebrand's disease (multiple).


    Mouse Vwf molecular target information


    Molecular name: Vwf, Von Willebrand factor


    Alternate names:

    • 6820430P06Rik
    • AI551257
    • B130011O06Rik
    • expressed sequence AI551257
    • RIKEN cDNA 6820430P06 gene
    • RIKEN cDNA B130011O06 gene


    Gene sequence:NCBI_Gene: 22371

    Protein sequence:


    Mouse Vwf target molecular function (prediction)


    Predicted to enable several functions, including chaperone binding activity; identical protein binding activity; and integrin binding activity. Acts upstream of or within several processes, including liver development; placenta development; and platelet activation. Located in external side of plasma membrane. Is expressed in several structures, including cardiovascular system; extraembryonic component; genitourinary system; disease 2. Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; Bernard-Soulier syndrome; end stage renal disease; essential thrombocythemia; and von Willebrand's disease (multiple). Orthologous to human VWF (von Willebrand factor).


    Rat Vwf molecular target information


    Molecular name: Vwf, von Willebrand factor

    Other names:

    • von Willebrand factor homolog

    Gene sequence:NCBI_Gene: 116669

    Protein sequence:


    Rat Vwf target molecular function (prediction)


    Predicted to enable several functions, including chaperone binding activity; identical protein binding activity; and integrin binding activity. Involved in several processes, including liver regeneration; platelet activation; and response to L-ascorbic acid. Located in collagen-containing extracellular matrix; endoplasmic reticulum; and extracellular space. Used to study transient cerebral ischemia. Biomarker of hypertension; mesangial proliferative glomerulonephritis; myocardial infarction; pulmonary fibrosis; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; Bernard-Soulier syndrome; end stage renal disease; essential thrombocythemia; and von Willebrand's disease (multiple). Orthologous to human VWF (von Willebrand factor).