KIT molecular target information overview
Overview of KIT molecular targets
CD117, also known as c-Kit, Steel factor receptor, and stem cell factor receptor, is a tyrosine kinase protein expressed primarily on hematopoietic progenitor cells, mast cells, and acute myeloid leukemia (AML) cells. CD117 activation promotes proliferation and differentiation of these cell subtypes. Lack or defective stem cell factor can lead to reduced numbers of hematopoietic progenitor cells and severe anemia. CD117 is also expressed by melanocytes and plays a role in signaling and activation of these cells.
Human KIT Molecular Target Information
Molecular name:KIT, KIT proto-oncogene, receptor tyrosine kinase
Alias:
- C-Kit
- c-Kit protooncogene
- CD117
- KIT proto-oncogene receptor tyrosine kinase
- mast/stem cell growth factor receptor
- mast/stem cell growth factor receptor Kit
- MASTC
- p145 c-kit
- PBT
- piebald trait
- piebald trait protein
- proto-oncogene c-Kit
- proto-oncogene tyrosine-protein kinase Kit
- SCFR
- soluble KIT variant 1
- tyrosine-protein kinase Kit
- v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
- v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein
Gene sequence:NCBI_Gene: 3815
Protein sequence:UniProtKB: P10721
Human KIT target molecular function (prediction)
Enables cytokine binding activity; protein homodimerization activity; and transmembrane receptor protein tyrosine kinase activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of macromolecule metabolic process; and positive regulation of signal transduction. Located in extracellular space; fibrillar center; and plasma membrane. Implicated in several diseases, including acute myeloid leukemia; gastrointestinal stromal tumor; germ cell cancer (multiple); piebaldism; and renal cell carcinoma. Biomarker of several diseases, including Hirschsprung's disease; invasive ductal carcinoma; oxyphilic adenoma; reproductive organ cancer (multiple); and urinary system cancer (multiple).
Mouse Kit Molecular Target Information
Molecular name:Kit, KIT proto-oncogene receptor tyrosine kinase
Alias:
- belly-spot
- Bs
- c-KIT
- CD117
- dominant spotting
- Dominant white spotting
- Fdc
- gsf spotted coat 1
- gsf spotted coat 5
- Gsfsco1
- Gsfsco5
- Gsfsow3
- phenotype like Sl or W 3
- SCO1
- SCO5
- SOW3
- spotted sterile male
- Ssm
- Steel Factor Receptor
- Tr-kit
- W
Gene sequence:NCBI_Gene: 16590
Protein sequence:
Mouse Kit Target Molecular Function (Prediction)
Acts upstream of or within several processes, including ectopic germ cell programmed cell death; hemopoiesis; and positive regulation of macromolecule metabolic process. Located in cell-cell junction and external side of plasma membrane. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; embryo mesenchyme; and genitourinary system. Used to study gastrointestinal stromal tumor; macrocytic anemia; mastocytosis; and piebaldism. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; gastrointestinal stromal tumor; germ cell cancer (multiple); piebaldism; Orthologous to human KIT (KIT proto-oncogene, receptor tyrosine kinase).
Rat Kit Molecular Target Information
Molecular name:Kit, KIT proto-oncogene receptor tyrosine kinase
Alias:
- c-kit receptor tyrosine kinase
- Kit oncogene
- mast/stem cell growth factor receptor
- mast/stem cell growth factor receptor Kit
- protein kinase
- v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Gene sequence:NCBI_Gene: 64030
Protein sequence:
Rat Kit target molecular function (prediction)
Enables protein tyrosine kinase activity. Involved in several processes, including gamete generation; positive regulation of gastro-intestinal system smooth muscle contraction; and protein phosphorylation. Located in acrosomal vesicle; cytoplasmic side of plasma membrane; and external side of plasma membrane. Used to study aplastic anemia and male infertility. Biomarker of acute pancreatitis and gastroschisis. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; gastrointestinal stromal tumor; germ cell cancer (multiple); piebaldism; and renal cell carcinoma. Orthologous to human KIT (KIT proto-oncogene, receptor tyrosine kinase).