CCL3 molecular target information overview
CCL3 molecular target review
Chemokine ligand 3 (CCL3), also known as macrophage inflammatory protein 1α (MIP-1α), is a cytokine in the CC chemokine family that participates in acute inflammatory states in the recruitment and activation of polymorphonuclear leukocytes. The CCL3 gene is located on human chromosome 17, and its cDNAs encode a 92 amino acid residue precursor protein with a 22 amino acid residue signal peptide, which can produce a secreted mature protein after cleavage. Like other chemokines, CCL3 is a monocyte chemoattractant. In addition, it has been reported that CCL3 has different chemotactic and adhesion-promoting effects on T lymphocytes, NK cells, cytotoxic T cells, B cells, basophils, and eosinophils. CCL3 has been identified as a stem cell inhibitor (SCI) that inhibits the proliferation of hematopoietic progenitor cells in vitro and in vivo. CCL3, CCL4, and RANTES are considered to be important HIV inhibitors produced by CD8+ T cells.
Human CCL3 Molecular Target Information
Molecular name: CCL3, CC motif chemokine ligand 3
Alias:
- CC motif chemokine 3
- chemokine (CC motif) ligand 3
- G0/G1 switch regulatory protein 19-1
- G0S19-1
- LD78 alpha beta
- LD78ALPHA
- macrophage inflammatory protein 1-alpha
- MIP-1-alpha
- MIP1A
- PAT 464.1
- SCYA3
- SIS-beta
- small inducible cytokine A3 (homologous to mouse Mip-1a)
- small-inducible cytokine A3
- tonsillar lymphocyte LD78 alpha protein
Gene sequence:NCBI_Gene: 6348
Protein sequence:UniProtKB: P10147
Human CCL3 target molecular function (prediction)
Enables several functions, including calcium-dependent protein kinase C activity; chemoattractant activity; and chemokine receptor binding activity. Involved in several processes, including cellular response to cytokine stimulus; leukocyte chemotaxis; and positive regulation of intracellular signal transduction. Located in cytosol and extracellular space. Implicated in human immunodeficiency virus infectious disease. Biomarker of COVID-19; alcoholic hepatitis; glomerulonephritis (multiple); kidney failure (multiple); and systemic scleroderma.
Mouse Ccl3 molecular target information
Molecular name: Ccl3, chemokine (CC motif) ligand 3
Alias:
- AI323804
- CCL3
- expressed sequence AI323804
- G0S19-1
- LD78alpha
- macrophage inflammatory protein-1 alpha
- macrophage inflammatory protein-1alpha
- MIP-1 alpha
- MIP-1alpha
- MIP1-(a)
- MIP1-alpha
- Mip1a
- Scya3
- small inducible cytokine A3
Gene sequence:NCBI_Gene: 20302
Protein sequence:
Mouse Ccl3 target molecular function (prediction)
Enables chemokine activity. Involved in several processes, including astrocyte cell migration; macrophage chemotaxis; and positive regulation of macromolecule metabolic process. Located in extracellular space. Is expressed in articular cartilage; cartilage; knee joint; lung;
Rat Ccl3 molecular target information
Molecular name: Ccl3, CC motif chemokine ligand 3
Alias:
- CC motif chemokine 3
- chemokine (CC motif) ligand 3
- macrophage inflammatory protein 1 alpha (Small inducible cytokine A3)
- macrophage inflammatory protein 1-alpha
- MIP-1-alpha
- MIP-1a
- Scya3
- small inducible cytokine A3
- small-inducible cytokine A3
Gene sequence:NCBI_Gene: 25542
Protein sequence:UniProtKB: P50229
Rat Ccl3 target molecular function (prediction)
Enables chemokine activity. Involved in several processes, including neutrophil chemotaxis; positive regulation of cytosolic calcium ion concentration; and positive regulation of osteoclast differentiation. Predicted to be located in cytosol and extracellular region. Predicted to be active in extracellular space. Biomarker of several diseases, including Chagas disease; anterior uveitis; nephritis (multiple); renal fibrosis; and status epilepticus. Human ortholog(s) of this gene implicated in human immunodeficiency virus infectious disease. Orthologous to several human genes including CCL3 (CC motif chemokine ligand 3).