HGF molecular target information overview
Overview of HGF molecular targets
Hepatocyte growth factor (HGF) is a paracrine cell growth, motility, and morphogenesis factor secreted by mesenchymal cells and serves as a multifunctional cytokine for most cells of epithelial origin. HGF exists as a single chain, a 728 amino acid residue propeptide with a 29 amino acid signal sequence and a 25 amino acid precursor sequence. HGF binds to the proto-oncogene c-Met receptor and activates a tyrosine kinase signaling cascade that regulates cell growth, motility, and morphogenesis. It plays a central role in angiogenesis, tumorigenesis, and tissue regeneration. Human HGF plasmid DNA is currently being tested for treatment of cardiomyocytes as a potential treatment for coronary artery disease and post-myocardial infarction heart damage. HGF has also been used as a prognostic indicator for chikungunya virus-induced arthralgia. High levels of HGF are associated with rapid recovery.
Human HGF molecular target information
Molecular name:HGF, hepatocyte growth factor
Alias:
- deafness, autosomal recessive 39
- DFNB39
- F-TCF
- fibroblast-derived tumor cytotoxic factor
- hepatocyte growth factor (hepapoietin A, scatter factor)
- hepatopoeitin-A
- hepatopoeitin-A
- HGFB
- HPTA
- lung fibroblast-derived mitogen
- SF
Gene sequence:NCBI_Gene: 3082
Protein sequence:UniProtKB: P14210
Human HGF target molecular function (prediction)
Enables chemoattractant activity and identical protein binding activity. Involved in several processes, including cellular response to hepatocyte growth factor stimulus; negative regulation of programmed cell death; and positive regulation of nitrogen compound metabolic process. Acts upstream of or within regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling. Located in membrane. Implicated in several diseases, including artery disease (multiple); autosomal recessive nonsyndromic deafness 39; eye disease (multiple); neuropathy (multiple); and scleroderma (multiple). Biomarker of several diseases, including artery disease (multiple); biliary tract disease (multiple); myositis (multiple); retinal disease (multiple); and rheumatoid arthritis (multiple).
Mouse Hgf molecular target information
Molecular name:Hgf, hepatocyte growth factor
Alias:
- C230052L06Rik
- HGF/SF
- NK1
- NK2
- RIKEN cDNA C230052L06 gene
- scatter factor
- SF/HGF
Gene sequence:NCBI_Gene: 15234
Protein sequence:
Mouse Hgf target molecular function (prediction)
Predicted to enable chemoattractant activity; growth factor activity; and identical protein binding activity. Acts upstream of or within several processes, including regulation of MAPK cascade; regulation of cytokine production; and regulation of protein phosphorylation. Predicted to be located in extracellular region. study autosomal recessive nonsyndromic deafness 39 and breast cancer. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autosomal recessive nonsyndromic deafness 39; eye disease (multiple); neuropathy (multiple); and scleroderma (multiple). Orthologous to human HGF (hepatocyte growth factor).
Rat Hgf molecular target information
Molecular name:Hgf, hepatocyte growth factor
Alias:
- hepatocyte growth factor (scatter factor)
- hepatopoeitin-A
- hepatopoeitin-A
- HPTA
- scatter factor
- SF
Gene sequence:NCBI_Gene: 24446
Protein sequence:UniProtKB: P17945
Rat Hgf target molecular function (prediction)
Enables growth factor activity. Involved in several processes, including animal organ regeneration; positive regulation of angiogenesis; and positive regulation of myelination. Located in extracellular space. Used to study brain infarction. Biomarker of cholangiocarcinoma. scleroderma (multiple). Orthologous to human HGF (hepatocyte growth factor).