CXCL1 molecular target information overview
Overview of CXCL1 molecular targets
Chemokine (CXC motif) ligand 1 (CXCL1) is a small molecular weight cytokine that belongs to the CXC chemokine family and has been previously known as GRO1 oncogene, GROα, KC, and neutrophil-activating protein 3 (NAP-3). In humans, the protein is encoded by the CXCL1 gene. CXCL1 is secreted by human melanoma cells, has mitogenic properties, and has been implicated in the pathogenesis of melanoma. CXCL1 is expressed by macrophages, neutrophils, and epithelial cells and has neutrophil chemotactic activity. This chemokine signals through the chemokine receptor CXCR2, which triggers its effects. CXCL1 plays a role in spinal cord development by inhibiting the migration of oligodendrocyte precursors. It is involved in angiogenesis, inflammation, wound healing, and tumorigenesis. Preliminary studies in mice suggest that CXCL1 reduces the severity of multiple sclerosis and provides neuroprotection.
Human CXCL1 Molecular Target Information
Molecular name: CXCL1, CXC motif chemokine ligand 1
Alias:
- CXC motif chemokine 1
- chemokine (CXC motif) ligand 1 (melanoma growth stimulating activity, alpha)
- fibroblast secretory protein
- FSP
- GRO-alpha(1-73)
- GRO1
- GRO1 oncogene (melanoma growth stimulating activity, alpha)
- GRO1 oncogene (melanoma growth-stimulating activity)
- GROa
- growth-regulated alpha protein
- melanoma growth stimulating activity, alpha
- melanoma growth stimulatory activity alpha
- MGSA
- MGSA alpha
- MGSA-a
- NAP-3
- neutrophil-activating protein 3
- SCYB1
Gene sequence:NCBI_Gene: 2919
Protein sequence:UniProtKB: P09341
Human CXCL1 target molecular function (prediction)
Predicted to enable CXCR chemokine receptor binding activity and chemokine activity. Involved in antimicrobial humoral immune response mediated by antimicrobial peptide and killing of cells of other organism. Predicted to be located in extracellular region; specific granule lumen; and tertiary granule lumen. Predicted to be active in extracellular space. Biomarker of asthma; chronic obstructive pulmonary disease; common cold; cystic fibrosis; and hyperhomocysteinemia.
Mouse Cxcl1 molecular target information
Molecular name: Cxcl1, chemokine (CXC motif) ligand 1
Alias:
- fibroblast secretory protein
- Fsp
- Gro1
- GRO1 oncogene
- KC
- KC/GRO-alpha
- melanoma growth stimulatory activity
- Mgsa
- N51
- Scyb1
Gene sequence:NCBI_Gene: 14825
Protein sequence:
Mouse Cxcl1 target molecular function (prediction)
Predicted to enable CXCR chemokine receptor binding activity and chemokine activity. Involved in positive regulation of hematopoietic stem cell proliferation; positive regulation of neutrophil mediated killing of fungus; and positive regulation of superoxide anion generation. Located in extracellular space. Is expressed in several structures, including gonad; liver; lung; nervous system; and retina. Orthologous to human CXCL2 (CXC motif chemokine ligand 2).
Rat Cxcl1 molecular target information
Molecular name: Cxcl1, CXC motif chemokine ligand 1
Alias:
- CXC motif chemokine 1
- chemokine (CXC motif) ligand 1
- chemokine (CXC motif) ligand 1 (melanoma growth stimulating activity, alpha)
- CINC-1
- cytokine-induced neutrophil chemoattractant 1
- Gro
- Gro1
- growth-regulated alpha protein
- platelet-derived growth factor-inducible protein KC
Gene sequence:NCBI_Gene: 81503
Protein sequence:
Rat Cxcl1 target molecular function (prediction)
Enables chemokine activity. Involved in several processes, including neutrophil chemotaxis; positive regulation of ion transport; and response to amphetamine. Located in extracellular space. Biomarker of several diseases, including acute necrotizing pancreatitis; pneumonia (multiple); prostatitis; severe acute respiratory syndrome; and status epilepticus. Orthologous to human CXCL1 (CXC motif chemokine ligand 1); CXCL2 (CXC motif chemokine ligand 2); and CXCL3 (CXC motif chemokine ligand 3).