Blog

LGALS3 molecular target information overview


  • Molecular name: LGALS3, galectin 3
  • Gene family: Receptor ligands; Galectins
  • Alias: MAC-2; GALIG
  • Former name: LGALS2
  • Alias: advanced glycation end-product receptor 3; lectin, galactoside-binding, soluble, 3


    • LGALS3 molecular target review


    Galectin-3 belongs to the lectin family and is expressed in the nucleus, cytoplasm, mitochondria, cell surface and extracellular space. Galectin-3 has affinity for β-galactosidase and exhibits antibacterial and antifungal activity. It is involved in many biological processes, such as cell adhesion, cell activation and chemotaxis, cell growth and differentiation, cell cycle and apoptosis. Based on its wide range of biological functions, Galectin-3 is believed to be related to cancer, inflammation and fibrosis, heart disease, stroke and so on. Galectin-3 expression levels are associated with various types of fibrosis. Galectin-3 expression is upregulated in liver fibrosis, kidney fibrosis and idiopathic pulmonary fibrosis (IPF). In people with acute decompensated heart failure and chronic heart failure, high expression of Galectin-3 leads to a higher risk of death. At the same time, Galectin-3 is believed to play an important role in tumor metastasis.


    Human LGALS3 Molecular Target Information


    Molecular name: LGALS3, galectin 3


    Alias:

    • 35 kDa lectin
    • advanced glycation end-product receptor 3
    • carbohydrate-binding protein 35
    • CBP35
    • GAL3
    • galactose-specific lectin 3
    • GALBP
    • galectin-3
    • GALIG
    • IgE-binding protein
    • L31
    • laminin-binding protein
    • lectin L-29
    • lectin, galactose binding, soluble 3
    • lectin, galactoside binding soluble 3
    • lectin, galactoside-binding, soluble, 3
    • LGALS2
    • MAC-2 antigen
    • MAC2

    Gene sequence:NCBI_Gene: 3958

    Protein sequence:UniProtKB: P17931


    Human LGALS3 target molecular function (prediction)


    Enables several functions, including IgE binding activity; chemoattractant activity; and laminin binding activity. Involved in several processes, including leukocyte chemotaxis; positive regulation of protein localization to plasma membrane; and regulation of apoptotic process. Located in immunological synapse; mitochondrial inner membrane; and nucleus. Is active in extracellular space. Colocalizes with collagen-containing extracellular matrix. Implicated in asthma. Biomarker of aortic valve stenosis and liver Cirrhosis.


    Mouse Lgals3 molecular target information


    Molecular name: Lgals3, lectin, galactose binding, soluble 3


    Alias:

    • gal3
    • galectin-3
    • L-34
    • Mac-2


    Gene sequence:NCBI_Gene: 16854

    Protein sequence:


    Mouse Lgals3 target molecular function (prediction)


    Predicted to enable several functions, including IgE binding activity; advanced glycation end-product receptor activity; and signaling receptor binding activity. Involved in negative regulation of T cell receptor signaling pathway; negative regulation of endocytosis; and negative regulation of lymphocyte activation. Acts upstream of or within extracellular matrix organization and skeletal system development. Located in several cellular components, including external side of plasma membrane; glial cell projection; and immunological synapse. Is expressed in several structures, including alimentary system; genitourinary system; respiratory system; skeleton; and skin. Used to study fatty liver disease. Human ortholog(s) of this gene implicated in asthma. Orthologous to human LGALS3 (galectin 3).


    Rat Lgals3 molecular target information


    Molecular name: Lgals3, galectin 3

    Alias:

    • 35 kDa lectin
    • AGE-R3
    • carbohydrate-binding protein 35
    • CBP 35
    • CBP30
    • epsilon BP
    • gal-3
    • galactose-specific lectin 3
    • galectin-3
    • IgE binding protein
    • L-34
    • laminin-binding protein
    • lectin galactoside-binding soluble 3 protein
    • lectin L-29
    • lectin, galactose binding, soluble 3
    • lectin, galactoside-binding, soluble, 3
    • mac-2 antigen
    • MGC105387

    Gene sequence:NCBI_Gene: 83781

    Protein sequence:


    Rat Lgals3 target molecular function (prediction)


    Enables several functions, including Fc-gamma receptor I complex binding activity; IgE binding activity; and advanced glycation end-product receptor activity. Involved in several processes, including negative regulation of cell proliferation in bone marrow; positive regulation of angiogenesis; and positive regulation of serotonin secretion. Located in several cellular components, including cell surface; extracellular space; and nucleus. Biomarker of several diseases, including acute kidney failure; deficit hyperactivity disorder; brain ischemia; congestive heart failure; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in asthma. Orthologous to human LGALS3 (galectin 3).