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CXCL5 molecular target information overview


  • Molecular name: CXCL5, CXC motif chemokine ligand 5
  • Gene family: Chemokine ligands
  • Alias: ENA-78
  • Former name: SCYB5
  • Alias: small inducible cytokine subfamily B (Cys-X-Cys), member 5 (epithelial-derived neutrophil-activating peptide 78); chemokine (CXC motif) ligand 5


    • Overview of CXCL5 molecular targets


    CXC motif chemokine 5 (CXCL5), also known as epithelial-derived neutrophil-activating peptide 78 (ENA-78), is a small molecular weight cytokine in the CXC chemokine family. CXCL5 can be produced after cells are stimulated by inflammatory cytokines IL-1 or TNF-α, and eosinophils can also express CXCL5, while type II interferon IFN-γ can inhibit its expression. CXCL5 exerts its effects by interacting with the cell surface chemokine receptor CXCR2, stimulating the chemotaxis of neutrophils with angiogenic properties and participating in connective tissue remodeling. CXCL5 also has the function of regulating neutrophil homeostasis. CXCL5 is highly expressed in atherosclerosis (a chronic inflammatory state), but is not associated with neutrophil infiltration. On the contrary, CXCL5 can directly control the formation of foam cells of macrophages, thereby protecting against atherosclerosis.


    Human CXCL5 Molecular Target Information


    Molecular name: CXCL5, CXC motif chemokine ligand 5


    Alias:

    • CXC motif chemokine 5
    • chemokine (CXC motif) ligand 5
    • ENA-78
    • ENA-78(1-78)
    • epithelial-derived neutrophil-activating protein 78
    • epithelial-derived neutrophil-activating peptide 78
    • epithelial-derived neutrophil-activating protein 78
    • neutrophil-activating peptide ENA-78
    • neutrophil-activating protein 78
    • SCYB5
    • small inducible cytokine B5
    • small inducible cytokine subfamily B (Cys-X-Cys), member 5 (epithelial-derived neutrophil-activating peptide 78)
    • small-inducible cytokine B5

    Gene sequence:NCBI_Gene: 6374

    Protein sequence: UniProtKB: P42830


    Human CXCL5 target molecular function (prediction)


    Enables identical protein binding activity. Predicted to be involved in several processes, including cellular response to lipopolysaccharide; chemokine-mediated signaling pathway; and neutrophil chemotaxis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Implicated in idiopathic pulmonary fibrosis. Biomarker of several diseases, including common cold; and sinusitis.


    Mouse Cxcl5 molecular target information


    Molecular name: Cxcl5, chemokine (CXC motif) ligand 5


    Alias:

    • AMCF-II
    • Cxcl6
    • ENA-78
    • GCP-2
    • granulocyte chemotactic protein-2
    • LIX
    • Scyb5
    • Scyb6
    • small inducible cytokine B subfamily, member 5
    • small inducible cytokine subfamily B, member 15


    Gene sequence:NCBI_Gene: 20311

    Protein sequence:


    Mouse Cxcl5 target molecular function (prediction)


    Predicted to enable CXCR chemokine receptor binding activity; chemokine activity; and protein binding activity. Acts upstream of or within several processes, including leukocyte homeostasis; regulation of neutrophil mediated killing of gram-negative bacterium; and response to lipopolysaccharide. Predicted to be located in extracellular region. Human ortholog(s) of this gene implicated in idiopathic pulmonary fibrosis. Orthologous to several human genes including CXCL6 (CXC motif chemokine ligand 6).