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Overview of ACE molecular target information


  • Molecular name: ACE, angiotensin I converting enzyme
  • Gene family: CD molecules
  • Alias: ACE1; CD143
  • Former name: DCP1
  • Alias: peptidyl-dipeptidase A; angiotensin I converting enzyme (peptidyl-dipeptidase A) 1


    • Overview of ACE molecular targets


    Angiotensin I converting enzyme (ACE), also known as dipeptidyl peptidase A, is a zinc metallopeptidase that is important for blood pressure control and water-salt metabolism. ACE converts angiotensin I to angiotensin II by releasing the terminal His-Leu dipeptide, thereby increasing the vasoconstrictor activity of angiotensin. It can also inactivate bradykinin, a potent vasodilator. ACE and ACE-2 are two cell surface proteases that are important regulators of the renin-angiotensin system (RAS) and play a key role in maintaining blood pressure homeostasis and water-salt balance in mammals. ACE exists in two forms in the human body, one expressed in somatic cells, called sACE (somatic ACE), and the other expressed in germ cells, called gACE (germinal ACE). The main difference between the two forms of ACE is that gACE contains only one C-terminal active functional region, while sACE contains two active functional regions at the C-terminus and N-terminus. Therefore, the catalytic activities of the two ACEs are different, and sACE plays a more critical role in the most important RAS pressor regulation system. ACE-2 consists of a protease domain and is an important regulator of cardiopulmonary function. It is also the cell receptor for the SARS virus that causes severe acute respiratory syndrome and the spike protein of the new coronavirus.


    Human ACE molecular target information


    Molecular name: ACE, angiotensin I converting enzyme


    Alias:

    • ACE1
    • angiotensin 1 converting enzyme 1
    • angiotensin converting enzyme, somatic isoform
    • angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
    • angiotensin I converting enzyme peptidyl-dipeptidase A 1 transcript
    • angiotensin-converting enzyme
    • carboxycathepsin
    • CD143
    • CD143 antigen
    • DCP
    • DCP1
    • dipeptidyl carboxypeptidase 1
    • dipeptidyl carboxypeptidase I
    • ICH
    • kininase II
    • MGC26566
    • MVCD3
    • peptidase P
    • testicular ECA

    Gene sequence:NCBI_Gene: 1636

    Protein sequence:UniProtKB: P12821


    Human ACE target molecular function (prediction)


    Enables several functions, including chloride ion binding activity; peptidase activity; and protein kinase binding activity. Involved in several processes, including arachidonic acid secretion; peptide metabolism process; and of angiotensin metabolism process. Located in several cellular components, including external side of plasma regulation; extracellular exosome; and lysosome. Implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); gastrointestinal system cancer (multiple); heart valve disease (multiple); and lung disease (multiple). Biomarker of several diseases, including chronic myeloid leukemia; intermediate coronary syndrome; lung disease (multiple); pancreatic ductal carcinoma; and renal fibrosis.


    Mouse Ace molecular target information


    Molecular name:Ace, angiotensin I converting enzyme (peptidyl-dipeptidase A) 1


    Alias:

    • AW208573
    • CD143
    • expressed sequence AW208573


    Gene sequence:NCBI_Gene: 11421

    Protein sequence:


    Mouse Ace target molecular function (prediction)


    Acts upstream of or within several processes, including heart contraction; neutrophil mediated immunity; and positive regulation of systemic arterial blood pressure. Located in cytoplasm and plasma membrane. Is expressed in several structures, including alimentary system; brain; extraembryonic component; genitourinary system; and integumental system. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); gastrointestinal system cancer (multiple); heart valve disease (multiple); and lung disease (multiple). Orthologous to human ACE (angiotensin I converting enzyme).


    Rat Ace molecular target information


    Molecular name: Ace, angiotensin I converting enzyme

    Alias:

    • angiotensin 1 converting enzyme
    • angiotensin 1 converting enzyme 1
    • angiotensin converting enzyme
    • angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
    • angiotensin I converting enzyme 1
    • angiotensin I-converting enzyme (Dipeptidyl carboxypeptidase 1)
    • angiotensin-converting enzyme
    • angiotensin-converting enzyme-like
    • CD143
    • Dcp1
    • Dipeptidyl carboxypeptidase 1
    • Dipeptidyl carboxypeptidase 1 (Angiotensin I-converting enzyme)
    • dipeptidyl carboxypeptidase I
    • kininase II
    • LOC102556346
    • StsRR92

    Gene sequence:NCBI_Gene: 24310

    Protein sequence:


    Rat Ace target molecular function (prediction)


    Enables heterocyclic compound binding activity; metallopeptidase activity; and peptidyl-dipeptidase activity. Involved in several processes, including animal organ development; negative regulation of transport; and response to corticosteroid. Located in several cellular components, including basal plasma membrane; brush border membrane; and sperm midpiece. Used to study several diseases, including artery disease (multiple); glomerulonephritis (multiple); kidney failure (multiple); lung disease (multiple); and proteinuria (multiple). Biomarker of several diseases, including artery disease (multiple); congenital diaphragmatic hernia; endomyocardial fibrosis; liver cirrhosis (multiple); and lung disease (multiple). (multiple). Orthologous to human ACE (angiotensin I converting enzyme).