CD80 molecular target information overview
CD80 molecular target review
Cluster of differentiation 80 (CD80) is a protein found on dendritic cells, activated B cells, and monocytes that provides an essential co-stimulatory signal for T cell activation and survival. It is also known as B7-1. The cDNA of B7-1 is predicted to be a type I membrane protein, a membrane protein synthesized on a signal peptide that is translocated on the endoplasmic membrane. The protein is predicted to contain two extracellular domains with a structure similar to that of Ig, a hydrophobic transmembrane region, and a short cytoplasmic domain. The CD80 and CD86 genes encode B7-1 and B7-2, respectively, which are structurally similar members of the immunoglobulin superfamily expressed on various hematopoietic cell types. B7-1 and B7-2 provide co-stimulatory signals to T cells by interacting with CD28 and CTLA4.
Human CD80 Molecular Target Information
Molecular name: CD80, CD80 molecule
Alias:
- activation B7-1 antigen
- B-lymphocyte activation antigen B7
- B7
- B7-1
- B7.1
- BB1
- CD28LG
- CD28LG1
- cd80 antigen
- CD80 antigen (CD28 antigen ligand 1, B7-1 antigen)
- costimulatory factor CD80
- costimulatory molecule variant IgV-CD80
- CTLA-4 counter-receptor B7.1
- LAB7
- T-lymphocyte activation antigen CD80
Gene sequence:NCBI_Gene: 941
Protein sequence: UniProtKB: P33681
Human CD80 target molecule function (prediction)
Predicted to enable virus receptor activity. Involved in positive regulation of peptidyl-tyrosine phosphorylation. Located in cell surface. Part of protein complex involved in cell adhesion. Implicated in type 1 diabetes mellitus. Biomarker of chronic obstructive pulmonary disease; demyelinating disease; relapsing-remitting multiple sclerosis; rheumatoid arthritis; and systemic lupus erythematosus.
Mouse Cd80 molecular target information
Molecular name: Cd80, CD80 antigen
Alias:
- B7-1
- B7.1
- CD28 antigen ligand
- Cd28l
- Ly-53
- Ly53
- lymphocyte antigen 53
Gene sequence:NCBI_Gene: 12519
Protein sequence:
Mouse Mouse Cd80 Target Molecular Function (Prediction)
Predicted to enable coreceptor activity. Acts upstream of or within T cell costimulation; cellular response to lipopolysaccharide; and positive regulation of alpha-beta T cell proliferation. Located in external side of plasma membrane. Is expressed in heart ventricle and skin. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human CD80 (CD80 molecule).
Rat Cd80 molecular target information
Molecular name: Cd80, Cd80 molecule
Alias:
- B7-1
- Cd80 a rat homolog of the human CD28/CTLA - 4 ligand (B7-1)
- CD80 antigen
- CD80-like
- LOC100360171
- T-lymphocyte activation antigen CD80
Gene sequence:NCBI_Gene: 25408
Protein sequence:
Rat Cd80 target molecular function (prediction)
Predicted to enable coreceptor activity. Involved in positive regulation of T cell proliferation. Located in cell surface. Used to study adult T-cell leukemia; anti-basement membrane glomerulonephritis; high grade glioma; and periodontal disease. Biomarker of kidney failure. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human CD80 (CD80 molecule).