CD33 molecular target information overview
CD33 molecular target review
The P67.6 monoclonal antibody reacts with human CD33 (also known as GP67 and P67), a 67kDa type I transmembrane glycoprotein that is a member of the Siglec (sialic acid-binding Ig superfamily lectin) family. CD33 is expressed in myeloid precursor cells, granulocytes, and monocytes, and the expression intensity of CD33 in normal people varies. CD33 is expressed in all AML subtypes, and 10% to 20% of ALL may also be accompanied by CD33 expression.
Human CD33 Molecular Target Information
Molecular name: CD33, CD33 molecule
Alias:
- CD33 antigen (gp67)
- CD33 molecule transcript
- FLJ00391
- gp67
- myeloid cell surface antigen CD33
- p67
- sialic acid binding Ig-like lectin 3
- sialic acid-binding Ig-like lectin 3
- SIGLEC-3
- SIGLEC3
Gene sequence:NCBI_Gene: 945
Protein sequence: UniProtKB: P20138
Human CD33 target molecule function (prediction)
Enables protein phosphatase binding activity and sialic acid binding activity. Involved in several processes, including negative regulation of cytokine production; negative regulation of monocyte activation; and positive regulation of protein tyrosine phosphatase activity. Located in several cellular components, including Golgi apparatus; external side of plasma membrane; and peroxisome.
Mouse Cd33 molecular target information
Molecular name: Cd33, CD33 antigen
Alias:
- gp67
- Siglec-3
Gene sequence:NCBI_Gene: 12489
Protein sequence:
Mouse Mouse Cd33 Target Molecular Function (Prediction)
Predicted to enable protein phosphatase binding activity and sialic acid binding activity. Predicted to be involved in several processes, including negative regulation of cytokine production; negative regulation of monocyte activation; and positive of protein tyrosine phosphatase activity. Predicted to be located in several cellular components, including Golgi apparatus; external side of plasma membrane; and peroxisome. Predicted to be active in plasma membrane. system; spleen; and submandibular gland. Orthologous to human CD33 (CD33 molecule).
Rat Cd33 molecular target information
Molecular name: Cd33, CD33 molecule
Alias:
- LOC690492
- myeloid cell surface antigen CD33
- similar to CD33 antigen
Gene sequence:NCBI_Gene: 690492
Protein sequence:UniProtKB: F1LTZ3
Rat Cd33 target molecular function (prediction)
Predicted to enable protein phosphatase binding activity and sialic acid binding activity. Predicted to be involved in several processes, including negative regulation of cytokine production; negative regulation of monocyte activation; and positive of protein tyrosine phosphatase activity. Predicted to be located regulation in several cellular components, including Golgi apparatus; external side of plasma membrane; molecule).