GDNF molecular target information overview
Overview of GDNF molecular targets
Glial cell line-derived neurotrophic factor (GDNF) is a neurotrophic factor that promotes the survival of different neuronal subpopulations at different stages of development of the central and peripheral nervous systems. The functional human GDNF ligand is a disulfide-linked homodimer consisting of two 15kDa polypeptide chains. GDNF is produced by supporting cells, type 1 astrocytes, Schwann cells, neurons, pinealocytes, and skeletal muscle cells. It is a secretory protein that promotes the survival of motor neurons, midbrain dopaminergic neurons, Purkinje cells, and sympathetic neurons. GDNF is 100 times more efficient than neurotrophins in the survival of spinal motor neurons. In a mouse model of Parkinson's disease, GDNF was found to improve conditions such as bradykinesia, rigidity, and postural instability.
Human GDNF molecular target information
Molecular name: GDNF, glial cell derived neurotrophic factor
Alias:
- astrocyte-derived trophic factor
- ATF
- ATF1
- ATF2
- glial cell line derived neurotrophic factor
- glial cell line-derived neurotrophic factor
- HFB1-GDNF
- hGDNF
- HSCR3
Gene sequence:NCBI_Gene: 2668
Protein sequence:UniProtKB: P39905
Human GDNF target molecular function (prediction)
Acts upstream of or within several processes, including neural crest cell migration; neuron projection development; and positive regulation of cell population proliferation. Located in Golgi apparatus and extracellular region. Implicated in Hirschsprung's disease; Parkinsonism; and epilepsy. Biomarker of acoustic neuroma; autoimmune disease (multiple); neurodegenerative disease (multiple); pancreatic cancer; and vasculitis (multiple).
Mouse Gdnf molecular target information
Molecular name: Gdnf, glial cell line derived neurotrophic factor
Alias:
- AI385739
- expressed sequence AI385739
- glial cell line-derived neurotrophic factor
Gene sequence:NCBI_Gene: 14573
Protein sequence:
Mouse Gdnf target molecular function (prediction)
Predicted to enable protein homodimerization activity and signaling receptor binding activity. Involved in several processes, including nervous system development; positive regulation of morphogenesis of an epithelium; and ureteric bud formation. Acts upstream of or within several processes, including negative regulation of neuron apoptotic process; nephron epithelium morphogenesis; and organ induction. Predicted to be located in Golgi apparatus and extracellular region. Predicted to be part of receptor complex. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and integumental system. Used to study Hirschsprung's disease. Human ortholog(s) of this gene implicated in Hirschsprung's disease; Parkinsonism; and epilepsy.
Rat Gdnf molecular target information
Molecular name: Gdnf, glial cell derived neurotrophic factor
Alias:
- astrocyte-derived trophic factor
- ATF
- glial cell line derived neurotrophic factor
- Glial cell line derived neutrophic factor
- glial cell line-derived neurotrophic factor
- GNDF
Gene sequence:NCBI_Gene: 25453
Protein sequence:
Rat Gdnf target molecular function (prediction)
Enables protein homodimerization activity and signaling receptor binding activity. Involved in several processes, including animal organ development; cellular response to dexamethasone stimulus; and regulation of morphogenesis of an epithelium. Located in extracellular space. Part of receptor complex. Used to study Parkinsonism and middle cerebral artery infarction. Biomarker of Parkinsonism and sciatic neuropathy. Human ortholog(s) of this gene implicated in Hirschsprung's disease; Parkinsonism; and epilepsy. Orthologous to human GDNF (glial cell derived neurotrophic factor).