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FGF19 molecular target information overview


  • Molecular name: FGF19, fibroblast growth factor 19
  • Gene family: Fibroblast growth factor family


    • Overview of FGF19 molecular targets


    Fibroblast growth factor 19 (FGF-19) is encoded by the FGF-19 gene in humans. FGF-19 regulates bile acid synthesis and inhibits CYP7A1 in the liver through the FGFR4/Klotho-β receptor complex. In mouse models, FGF-19 also has metabolic effects, affecting glucose and lipid metabolism. FGF-19 is reduced in patients with chronic diarrhea due to bile acid malabsorption. FGF-19 is also present in the liver of patients with cholestasis. FGF-19 expression is reduced in patients with metabolic syndrome, non-alcoholic fatty liver disease, and insulin resistance. However, FGF-19 is increased to normal levels in obese patients who undergo Roux-en-Y gastric bypass surgery.


    Human FGF19 Molecular Target Information


    Molecular name: FGF19, fibroblast growth factor 19


    Other Names:

    • FGF-19

    Gene sequence:NCBI_Gene: 9965

    Protein sequence:UniProtKB: O95750


    Human FGF19 target molecular function (prediction)


    Enables fibroblast growth factor receptor binding activity. Involved in several processes, including negative regulation of bile acid biosynthetic process; positive regulation of MAPK cascade; and positive regulation of glucose import. Acts upstream of or within fibroblast growth factor receptor signaling pathway and positive regulation of cell population proliferation. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and extracellular space.


    Mouse Fgf15 molecular target information


    Molecular name:Fgf15, fibroblast growth factor 15


    Alias:

    • FGF19


    Gene sequence:NCBI_Gene: 14170

    Protein sequence:


    Mouse Fgf15 target molecular function (prediction)


    Predicted to enable fibroblast growth factor receptor binding activity and growth factor activity. Acts upstream of or within several processes, including negative regulation of bile acid biosynthetic process; neural crest cell migration; and response to bacterium. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and extracellular space. Is expressed in several structures, including brain; branchial arch endoderm; embryo ectoderm; mesonephros; Orthologous to human FGF19 (fibroblast growth factor 19).


    Rat Fgf19 molecular target information


    Molecular name: Fgf19, fibroblast growth factor 19

    Alias:

    • Fgf15
    • Fgf8a
    • fibroblast growth factor 15
    • fibroblast growth factor 8a

    Gene sequence:NCBI_Gene: 170582

    Protein sequence:UniProtKB: Q8VI81


    Rat Fgf19 target molecular function (prediction)


    Predicted to enable fibroblast growth factor receptor binding activity and growth factor activity. Involved in bile acid and bile salt transport; response to ethanol; and response to organic cyclic compound. Predicted to be active in cytoplasm and extracellular space. Biomarker of alcoholic hepatitis. Orthologous to human FGF19 (fibroblast growth factor 19).