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TIMP2 molecular target information overview


  • Molecular name: TIMP2, TIMP metallopeptidase inhibitor 2
  • Gene family: Tissue inhibitor of metallopeptidases
  • Alias: CSC-21K
  • Alias: tissue inhibitor of metalloproteinase 2


    • Overview of TIMP2 molecular targets


    The tissue inhibitor of metalloproteinase 2 (TIMP2) gene is a member of the TIMP gene family. Among the four known members of the TIMP family, TIMP-2 has both common features of all TIMPs and its own unique features. The proteins encoded by this gene family are natural inhibitors of matrix metalloproteinases (MMPs), a group of peptidases involved in the degradation of the extracellular matrix. TIMP2 acts as both an inhibitor and an activator of MMPs. TIMP-1 inhibits the activity of MMP-7, MMP-9, MMP-1, and MMP-3 better than TIMP-2, while TIMP-2 inhibits the activity of MMP-2 more effectively than other TIMPs. In melanocytes, the expression of the TIMP2 gene may be regulated by MITF. Recent studies have found that TIMP2 plays an important role in hippocampal function and cognitive function.


    Human TIMP2 molecular target information


    Molecular name: TIMP2, TIMP metallopeptidase inhibitor 2


    Alias:

    • CSC-21K
    • DDC8
    • KIAA1731NL
    • metalloproteinase inhibitor 2
    • testicular secretory protein Li 57
    • TIMP-2
    • tissue inhibitor of metalloproteinase 2
    • tissue inhibitor of metalloproteinases 2

    Gene sequence:NCBI_Gene: 7077

    Protein sequence:UniProtKB: P16035


    Human TIMP2 target molecular function (prediction)


    Enables peptidase inhibitor activity; protease binding activity; and zinc ion binding activity. Involved in negative regulation of metallopeptidase activity. Located in collagen-containing extracellular matrix. Implicated in Moyamoya disease. Biomarker of several diseases, including Duchenne muscular dystrophy; aortic disease (multiple); carcinoma (multiple); neurodegenerative disease (multiple); and preretinal fibrosis.


    Mouse Timp2 molecular target information


    Molecular name:Timp2, tissue inhibitor of metalloproteinase 2


    Alias:

    • D11Bwg1104e
    • DNA segment, Chr 11, Brigham & Women's Genetics 1104 expressed
    • Timp-2
    • TIMP-2


    Gene sequence:NCBI_Gene: 21858

    Protein sequence:


    Mouse Timp2 target molecular function (prediction)


    Enables enzyme activator activity; integrin binding activity; and metalloendopeptidase inhibitor activity. Acts upstream of or within several processes, including negative regulation of cell population proliferation; regulation of MAPK cascade; and regulation of neuron differentiation. Located in basement membrane and cell surface. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; Moyamoya disease. Orthologous to human TIMP2 (TIMP metallopeptidase inhibitor 2).


    Rat Timp2 molecular target information


    Molecular name: Timp2, TIMP metallopeptidase inhibitor 2

    Alias:

    • metalloproteinase inhibitor 2
    • MGC105282
    • TIMP-2
    • tissue inhibitor of metalloproteinase 2
    • tissue inhibitor of metalloproteinases 2

    Gene sequence:NCBI_Gene: 29543

    Protein sequence:UniProtKB: P30121


    Rat Timp2 target molecular function (prediction)


    Enables integrin binding activity and metalloendopeptidase inhibitor activity. Involved in several processes, including positive regulation of adenylate cyclase activity; positive regulation of neuron differentiation; and regulation of intracellular signal transduction. Located in several cellular components, including cell surface; growth cone; and neuronal cell body. Used to study portal hypertension. Biomarker of cardiomyopathy; congestive heart failure; and intracranial aneurysm. Human ortholog(s) of this gene implicated in Moyamoya disease. Orthologous to human TIMP2 (TIMP metallopeptidase inhibitor 2).