ANGPT2 molecular target information overview
Overview of ANGPT2 molecular targets
Angiopoietin-2 (ANG-2) is a secreted glycoprotein with a molecular weight of approximately 70 kDa. It plays a complex role in angiogenesis, inflammation, and vascular development. It is expressed in vascular endothelial cells and smooth muscle cells in highly angiogenic tissues, lung epithelial cells, differentiated myotubes, and neural progenitor cells. ANG-2 promotes the survival, proliferation, and migration of endothelial cells and promotes sprouting angiogenesis. It induces the loss of pericytes in the vascular wall and increases vascular permeability. ANG-2 is essential for the development of lymphatic vessels and the postnatal remodeling of lymphatic vessels and blood vessels. ANG-2 levels are elevated in patients with angiosarcoma, and studies have shown that ANG-2 is involved in the pathogenesis of septic shock. Serum ANG-2 expression is associated with the growth, angiogenesis, and overall survival of multiple myeloma and oral squamous cell carcinoma. Circulating ANG-2 is a marker of early cardiovascular disease in children on chronic dialysis, and Kaposi's sarcoma-associated herpes virus causes rapid release of ANG-2 from endothelial cells.
Human ANGPT2 Molecular Target Information
Molecular name: ANGPT2, angiopoietin 2
Alias:
- AGPT2
- ANG-2
- ANG2
- angiopoietin-2
- angiopoietin-2a
- angiopoietin-2B
- LMPHM10
- Tie2-ligand
Gene sequence:NCBI_Gene: 285
Protein sequence: UniProtKB: O15123
Human ANGPT2 target molecular function (prediction)
Enables receptor tyrosine kinase binding activity. Involved in Tie signaling pathway; negative regulation of blood vessel endothelial cell migration; and negative regulation of positive chemotaxis. Acts upstream of or within gene expression. Located in extracellular space. Implicated in hereditary lymphedema. Biomarker of COVID-19; endometrial adenocarcinoma; transitional cell carcinoma; and type 2 diabetes mellitus.
Mouse Angpt2 molecular target information
Molecular name: Angpt2, angiopoietin 2
Alias:
- Ang-2
- Ang2
Gene sequence:NCBI_Gene: 11601
Protein sequence:
Mouse Angpt2 target molecular function (prediction)
Predicted to enable receptor tyrosine kinase binding activity. Acts upstream of or within angiogenesis; negative regulation of angiogenesis; and negative regulation of cell-substrate adhesion. Located in extracellular space. Is expressed in several structures, including cardiovascular system; central nervous system; hemolymphoid system; limb interdigital region; and urinary system. Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to human ANGPT2 (angiopoietin 2).
Rat Angpt2 molecular target information
Molecular name: Angpt2, angiopoietin 2
Alias:
- Agpt2
- Ang-2
- angiopoietin-2
Gene sequence:NCBI_Gene: 89805
Protein sequence:UniProtKB: O35462
Rat Angpt2 target molecular function (prediction)
Predicted to enable receptor tyrosine kinase binding activity. Involved in several processes, including blood vessel development; maternal process involved in female pregnancy; and positive regulation of angiogenesis. Located in several cellular components, including extracellular space; nucleus; and plasma membrane. Used to study several diseases, including ischemia (multiple); membranenoproliferative glomerulonephritis; portal hypertension; retinal disease (multiple); and uremia. artery disease (multiple); glomerulonephritis (multiple); musculoskeletal system cancer (multiple); and retinal disease (multiple). Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to human ANGPT2 (angiopoietin 2).