CIITA molecular target information overview
CIITA molecular target review
MHC stands for Major Histocompatibility Complex, which is a group of closely linked genes that determine whether transplanted tissues are compatible, are closely related to immune responses, and are only present in antigen presenting cells and lymphocytes. MHC Class II contains two chains, namely α and β chains, each of which contains two regions. The α chain contains the α1 and α2 regions, and the β chain contains the β1 and β2 regions. α2 and β2 are transmembrane domains that anchor the MHC Class II molecules to the cell membrane. The polypeptide binding site exists between the heterodimers formed by α1 and β1.
Human CIITA Molecular Target Information
Molecular name:CIITA, class II major histocompatibility complex transactivator
Alias:
- C2TA
- CIITAIV
- class II, major histocompatibility complex, transactivator
- MHC class II transactivator
- MHC class II transactivator type I
- MHC class II transactivator type III
- MHC2TA
- NLR family, acid domain containing
- NLRA
- nucleotide-binding oligomerization domain, leucine rich repeat and acid domain containing
Gene sequence:NCBI_Gene: 4261
Protein sequence: UniProtKB: P33076
Human CIITA target molecular function (prediction)
Enables DNA-binding transcription factor binding activity; protein C-terminus binding activity; and transcription cis-regulatory region binding activity. Involved in negative regulation of viral entry into host cell; regulation of macromolecule biosynthetic process; and response to interferon-gamma. infarction.
Mouse Ciita Molecular Target Information
Molecular Name: Ciita, class II transactivator
Alias:
- C2ta
- EG669998
- Gm9475
- predicted gene 9475
- predicted gene, EG669998
Gene sequence:NCBI_Gene: 12265
Protein sequence:
- UniprotKB: P79621
- UniprotKB: A0A2R8VHC7
- UniprotKB: A0A2R8VHL9
- UniprotKB: A0A2R8W6Z7
- UniprotKB: Q3KND9
- UniprotKB: Q3KNE0
- UniprotKB: Q3TR57
- UniprotKB: Q3U2F8
- UniprotKB: Q3U2P0
- UniprotKB: Q3U5G4
- UniprotKB: Q3UNW8
- UniprotKB: Q3UU40
- UniprotKB: Q8HW99
Mouse Ciita Target Molecular Function (Prediction)
Predicted to enable DNA-binding transcription factor binding activity; protein C-terminus binding activity; and transcription cis-regulatory region binding activity. Involved in positive regulation of transcription by RNA polymerase II and response to interferon-gamma. Acts upstream of or within negative regulation of transcription, DNA-templated. Predicted to be located in PML body; cell surface; and cytosol. Is expressed in bladder; central nervous system; and retina. Used to study MHC class II deficiency and osteoporosis. Human ortholog(s) of this gene implicated in Addison's disease; MHC class II deficiency; autoimmune disease (multiple); and myocardial infarction. Orthologous to human CIITA (class II major histocompatibility complex transactivator).
Rat Ciita Molecular Target Information
Molecular name:Ciita, class II, major histocompatibility complex, transactivator
Alias:
- C2ta
- class II transactivator
- MHC class II transactivator
- MHC class II transactivator type IV
- Mhc2ta
Gene sequence:NCBI_Gene: 85483
Protein sequence:
- UniprotKB: A0A0G2JVN3
- UniprotKB: A0A0G2K9Q5
- UniprotKB: G3V6C0
- UniprotKB: Q9GJD8
- UniprotKB: Q9GJD9
- UniprotKB: Q9GJE0
Rat Ciita target molecular function (prediction)
Predicted to enable DNA-binding transcription factor binding activity; protein C-terminus binding activity; and transcription cis-regulatory region binding activity. Involved in several processes, including cellular response to electrical stimulus; cellular response to exogenous dsRNA; and regulation of macromolecule biosynthetic process. Located in cell surface. Used to study periapical periodontitis. Human ortholog(s) of this gene implicated in Addison's disease; MHC class II deficiency; autoimmune disease (multiple); and myocardial infarction. Orthologous to human CIITA (class II major histocompatibility complex transactivator).