FGF2 molecular target information overview
Overview of FGF2 molecular targets
Basic fibroblast growth factor (FGFbasic), also known as bFGF, FGF2 or FGF-β, is a member of the fibroblast growth factor family. During wound healing and tumor development in normal tissues, heparan sulfate degrading enzymes activate FGFbasic to mediate angiogenesis. In addition, human adipocytes can synthesize and secrete FGFbasic, and its concentration is correlated with BMI in blood samples. Studies have shown that low levels of FGFbasic play an important role in the occurrence of excessive anxiety. In addition, FGFbasic is an important component of human embryonic stem cell culture medium and is a necessary factor for maintaining the undifferentiated state of cells. FGFbasic, together with BMP4, can promote stem cell differentiation into the mesodermal lineage. Compared with untreated stem cells, stem cells treated with BMP4 and FGFbasic usually differentiate into more osteoblasts and chondrocytes.
Human FGF2 Molecular Target Information
Molecular name: FGF2, fibroblast growth factor 2
Alias:
- basic fibroblast growth factor bFGF
- BFGF
- FGF-2
- FGFB
- fibroblast growth factor 2 (basic)
- HBGF-2
- heparin-binding growth factor 2
- prostatropin
Gene sequence:NCBI_Gene: 2247
Protein sequence:UniProtKB: P09038
Human FGF2 target molecular function (prediction)
Enables several functions, including identical protein binding activity; nuclear receptor coactivator activity; and signaling receptor binding activity. Involved in several processes, including positive regulation of cell population proliferation; positive regulation of intracellular signal transduction; and regulation of cell migration. Acts upstream of or within positive regulation of cell fate specification and positive regulation of cell population proliferation. Located in extracellular space. Implicated in several diseases, including Parkinsonism; corneal neovascularization; diabetic neuropathy; gastric ulcer; and impotence. Biomarker of several diseases, including artery disease (multiple); breast cancer (multiple); carcinoma (multiple); eye disease (multiple); and female reproductive organ cancer (multiple).
Mouse Fgf2 molecular target information
Molecular name: Fgf2, fibroblast growth factor 2
Alias:
- bFGF
- Fgf-2
- Fgfb
- fibroblast growth factor, basic
Gene sequence:NCBI_Gene: 14173
Protein sequence:
Mouse Fgf2 target molecular function (prediction)
Enables growth factor activity. Involved in stem cell development. Acts upstream of or within several processes, including animal organ development; positive regulation of macromolecule metabolic process; and positive regulation of signal transduction. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; extraembryonic component; genitourinary system; neuropathy; gastric ulcer; and impotence. Orthologous to human FGF2 (fibroblast growth factor 2).
Rat Fgf2 molecular target information
Molecular name: Fgf2, fibroblast growth factor 2
Alias:
- angiogenesis promoting growth factor
- basic fibroblast growth factor
- bFGF
- Fgf-2
- Fgf2a
- fibroblast growth factor 2a
- HBGF-2
- heparin binding growth factor
- heparin-binding growth factor 2
Gene sequence:NCBI_Gene: 54250
Protein sequence:
Rat Fgf2 target molecular function (prediction)
Enables fibroblast growth factor receptor binding activity. Involved in several processes, including angiogenesis involved in coronary vascular morphogenesis; paracrine signaling; and positive regulation of cell population proliferation. Acts upstream of or within fibroblast growth factor receptor signaling pathway. Located in cytoplasm; extracellular space; and nucleus. Used to study hypertension pulmonary. Biomarker of bladder disease; decubitus ulcer; diabetic retinopathy; hypertension; and retinal vein occlusion. Human Ortholog(s) of this gene implicated in several diseases, including Parkinsonism; corneal neovascularization; diabetic neuropathy; gastric ulcer; and impotence. Orthologous to human FGF2 (fibroblast growth factor 2).