CSF3 molecular target information overview
Overview of CSF3 molecular targets
Granulocyte colony stimulating factor (G-CSF) is a glycoprotein that stimulates the bone marrow to produce granulocytes and stem cells and release them into the blood. Functionally, it is a cytokine and hormone, a colony stimulating factor, produced by endothelial cells, macrophages and many other immune cells. G-CSF stimulates the survival, proliferation, differentiation and function of neutrophil precursors and mature neutrophils. In oncology and hematology, recombinant G-CSF is used to accelerate the recovery of chemotherapy-induced neutropenia in cancer patients. G-CSF can also be used to increase the number of hematopoietic stem cells in the blood of blood donors before leukocyte removal for hematopoietic stem cell transplantation.
Human CSF3 molecular target information
Molecular name: CSF3, colony stimulating factor 3
Alias:
- C17orf33
- chromosome 17 open reading frame 33
- colony stimulating factor 3 (granulocyte)
- CSF3OS
- filgrastim
- G-CSF
- GCSF
- granulocyte colony-stimulating factor
- granulocyte-colony stimulating factor
- lenograstim
- MGC45931
- pluripoietin
Gene sequence:NCBI_Gene: 1440
Protein sequence:UniProtKB: P09919
Human CSF3 target molecular function (prediction)
Enables cytokine activity and enzyme binding activity. Involved in several processes, including positive regulation of cytoskeleton organization; positive regulation of intracellular signal transduction; and positive regulation of protein phosphorylation. Predicted to be located in endocytic vesicle lumen; extracellular region; and lysosomal lumen. (multiple); leukemia (multiple); and lung disease (multiple). Biomarker of COVID-19; bacterial pneumonia; and myeloid leukemia.
Mouse Csf3 molecular target information
Molecular name: Csf3, colony stimulating factor 3 (granulocyte)
Alias:
- colony stimulating factor, granulocyte
- Csfg
- G-CSF
- MGI-IG
Gene sequence:NCBI_Gene: 12985
Protein sequence:
Mouse Csf3 target molecular function (prediction)
Enables granulocyte colony-stimulating factor receptor binding activity. Acts upstream of or within positive regulation of myeloid cell differentiation. Predicted to be located in endocytic vesicle lumen and extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including brain; dorsal aorta; liver; reproductive system; and yolk sac. Human ortholog(s) of this gene implicated in several diseases, including allergic cutaneous vasculitis; artery disease (multiple); ischemia (multiple); leukemia (multiple); and lung disease (multiple). Orthologous to human CSF3 (colony stimulating factor 3).
Rat Csf3 molecular target information
Molecular name: Csf3, colony stimulating factor 3
Alias:
- colony stimulating factor 3 (granulocyte)
- Gcsf
- granulocyte colony-stimulating factor
Gene sequence:NCBI_Gene: 25610
Protein sequence:UniProtKB: P97712
Rat Csf3 target molecular function (prediction)
Enables growth factor activity. Involved in several processes, including cellular response to lipopolysaccharide; negative regulation of neuron death; and response to ethanol. Located in extracellular space. Biomarker of cystitis; lung disease; and middle cerebral artery infarction. Human ortholog(s) of this gene implicated in several diseases, including allergic cutaneous vasculitis; artery disease (multiple); ischemia (multiple); leukemia (multiple); and lung disease (multiple). Orthologous to human CSF3 (colony stimulating factor 3).