CST3 molecular target information overview
CST3 molecular target review
Cystatin C belongs to the cysteine protease inhibitor superfamily and is a potent inhibitor of lysosomal proteases. It may be one of the most important extracellular inhibitors of cysteine proteases. It is present in almost all tissues and body fluids, including plasma, urine, and cerebrospinal fluid. Cystatin C participates in a variety of disease processes by regulating the activity of cysteine proteases. Cystatin C is mainly used as a biomarker of renal function. Recently, studies have shown that it plays a role in predicting new or worsening cardiovascular disease. In addition, it plays a role in amyloid-related brain diseases such as Alzheimer's disease.
Human CST3 Molecular Target Information
Molecular name: CST3, cystatin C
Alias:
- ARMD11
- bA218C14.4 (cystatin C)
- cystatin 3
- cystatin C (amyloid angiopathy and cerebral hemorrhage)
- cystatin-3
- cystatin-C
- epididymis secretory protein Li 2
- gamma-trace
- HEL-S-2
- MGC117328
- neuroendocrine basic polypeptide
- post-gamma-globulin
Gene sequence:NCBI_Gene: 1471
Protein sequence:UniProtKB: P01034
Human CST3 target molecular function (prediction)
Enables several functions, including amyloid-beta binding activity; cysteine-type endopeptidase inhibitor activity; and identical protein binding activity. Involved in several processes, including negative regulation of blood vessel remodeling; negative regulation of catabolic process; and negative regulation of extracellular matrix disassembly. Located in Golgi apparatus; extracellular space; and plasma membrane. Implicated in CST3-related cerebral amyloid angiopathy and age related macular degeneration 11. Biomarker of several diseases, including artery disease (multiple); autoimmune disease of the nervous system (multiple); brain ischemia; obesity; and type 2 diabetes mellitus.
Mouse Cst3 molecular target information
Molecular name: Cst3, cystatin C
Alias:
- CysC
Gene sequence:NCBI_Gene: 13010
Protein sequence:
Mouse Cst3 target molecular function (prediction)
Predicted to enable several functions, including amyloid-beta binding activity; cysteine-type endopeptidase inhibitor activity; and identical protein binding activity. Predicted to be involved in several processes, including negative regulation of cell death; positive regulation of DNA replication; and response to oxidative stress. Predicted to act upstream of or within negative regulation of peptidase activity. Located in collagen-containing extracellular matrix and extracellular space. Is expressed in several structures, including central nervous system; early conceptus; heart; reproductive system; and visual system. Human ortholog(s) of this gene implicated in CST3-related cerebral amyloid angiopathy and age related macular degeneration 11. Orthologous to several human genes including CST3 (cystatin C).
Rat Cst3 molecular target information
Molecular name: Cst3, cystatin C
Alias:
- CYSC
- cystatin 3
- Cystatin C (cysteine proteinase inhibitor)
- cystatin-3
- cystatin-C
- MGC105556
Gene sequence:NCBI_Gene: 25307
Protein sequence: UniProtKB: P14841
Rat Cst3 target molecular function (prediction)
Enables peptidase inhibitor activity and protease binding activity. Involved in several processes, including animal organ development; circadian sleep/wake cycle, REM sleep; and embryo implantation. Located in several cellular components, including multivesicular body; neuronal cell body; and nuclear membrane. Biomarker of intracranial aneurysm; iron deficiency anemia; and obesity. Human ortholog(s) of this gene implicated in CST3-related cerebral amyloid angiopathy and age related macular degeneration 11. Orthologous to several human genes including CST3 (cystatin C).