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CD69 molecular target information overview


  • Molecular name: CD69, CD69 molecule
  • Gene family: CD molecules; C-type lectin domain containing
  • Alias: CLEC2C
  • Alias: CD69 antigen (p60, early T-cell activation antigen)


    • CD69 molecular target review


    CD69 is a type II transmembrane glycoprotein that belongs to the C-type lectin receptor family and is also a member of the NK cell signal transduction gene complex family. It is the earliest surface antigen expressed after T lymphocyte activation. When expressed, it can act as a co-stimulatory signal to promote further activation and proliferation of T cells. CD69 is also induced to express on NK cells, B cells, macrophages, neutrophils and eosinophils. Activated T cells expressing CD69 are mainly CD8+CD45RO+, and are mainly induced by IL-15 and are related to contact with activated endothelial cells expressing ICAM-1. When exogenous stimulation disappears, the expression of CD69 on activated T cells can decrease rapidly. Therefore, the degree of CD69 expression by lymphocytes after exposure to a certain antigen stimulation can reflect the degree of cell response to the antigen.


    Human CD69 Molecular Target Information


    Molecular name: CD69, CD69 molecule


    Alias:

    • activation inducer molecule (AIM/CD69)
    • AIM
    • BL-AC/P26
    • C-type lectin domain family 2 member C
    • C-type lectin domain family 2, member C
    • CD69 antigen (p60, early T-cell activation antigen)
    • CLEC2C
    • EA1
    • early activation antigen CD69
    • early lymphocyte activation antigen
    • early T-cell activation antigen p60
    • GP32/28
    • leukocyte surface antigen Leu-23
    • MLR-3

    Gene sequence:NCBI_Gene: 969

    Protein sequence: UniProtKB: Q07108


    Human CD69 target molecule function (prediction)


    Enables identical protein binding activity. Predicted to act upstream of or within cellular response to xenobiotic stimulus. Part of protein-containing complex.


    Mouse Cd69 molecular target information


    Molecular name: Cd69, CD69 antigen


    Alias:

    • 5830438K24Rik
    • AI452015
    • AIM
    • EST AI452015
    • RIKEN cDNA 5830438K24 gene
    • VEA


    Gene sequence:NCBI_Gene: 12515

    Protein sequence:


    Mouse Mouse Cd69 Target Molecular Function (Prediction)


    Predicted to enable calcium ion binding activity and identical protein binding activity. Located in external side of plasma membrane. Orthologous to human CD69 (CD69 molecule).


    Rat Cd69 molecular target information


    Molecular name: Cd69, Cd69 molecule

    Alias:

    • C-type lectin domain family 2 member A
    • CD69 antigen
    • early activation antigen CD69

    Gene sequence:NCBI_Gene: 29187

    Protein sequence:UniProtKB: Q5M851


    Rat Cd69 target molecular function (prediction)


    Enables calcium ion binding activity. Predicted to be involved in complement activation, lectin pathway. Predicted to act upstream of or within cellular response to xenobiotic stimulus. Predicted to be located in cell surface. Predicted to be part of protein-containing complex. Predicted to be active in external side of plasma membrane. Orthologous to human CD69 (CD69 molecule).