CXCL9 molecular target information overview
CXCL9 molecular target review
Chemokine CXC ligand 9 (CXCL9), also known as monokine induced by gamma interferon (MIG), is a small molecular weight cytokine belonging to the CXC chemokine family. It is closely related to the other two CXC chemokines, CXCL10 and CXCL11, which all interact with the chemokine receptor CXCR3 to exert their chemotactic function. CXCL9 is involved in Th1-type inflammation and has many functions, the main one being chemoattraction. Activated B cells, monocytes, CD8+ memory T cells, and CD4+ Th1 T cells can all respond to CXCL9. CXCL9 can also promote Th1 responses by acting as an antagonist of IL-4/Th2 responses, which occurs by blocking Th2-related chemokines (eotaxin), thereby limiting Th2 infiltration. CXCL9 can also exhibit direct antimicrobial activity through its extended C-terminus. In hematopoiesis, CXCL9 is involved in the mobilization and migration of CD34+ stem cells and inhibits the formation of erythroid and myeloid cell colonies.
Human CXCL9 Molecular Target Information
Molecular name: CXCL9, CXC motif chemokine ligand 9
Alias:
- CXC motif chemokine 9
- chemokine (CXC motif) ligand 9
- CMK
- crg-10
- gamma-interferon-induced monokine
- Humig
- MIG
- monokine induced by gamma interferon
- monokine induced by interferon-gamma
- SCYB9
- small-inducible cytokine B9
Gene sequence:NCBI_Gene: 4283
Protein sequence: UniProtKB: Q07325
Human CXCL9 target molecular function (prediction)
Enables CXCR3 chemokine receptor binding activity and chemokine activity. Involved in several processes, including adenylate cyclase-activating G protein-coupled receptor signaling pathway; antimicrobial humoral immune response mediated by antimicrobial peptide; and positive regulation of release of sequestered calcium ion into cytosol. Predicted to be located in extracellular area. cystic fibrosis; lung disease (multiple); severe acute respiratory syndrome; and thoracic aortic aneurysm.
Mouse Cxcl9 molecular target information
Molecular name: Cxcl9, chemokine (CXC motif) ligand 9
Alias:
- BB139920
- CMK
- crg-10
- expressed sequence BB139920
- Mig
- monokine induced by gamma interferon
- Scyb9
- small inducible cytokine B subfamily (Cys-X-Cys), member 9
Gene sequence:NCBI_Gene: 17329
Protein sequence:
Mouse Cxcl9 target molecular function (prediction)
Predicted to enable CXCR3 chemokine receptor binding activity and chemokine activity. Acts upstream of or within several processes, including defense response to virus; positive regulation of myoblast differentiation; and positive regulation of myoblast fusion. Located in external side of plasma membrane and extracellular space. Is expressed in central nervous system; retina; stomach; testis; and thymus. Orthologous to human CXCL9 (CXC motif chemokine ligand 9).
Rat Cxcl9 molecular target information
Molecular name: Cxcl9, CXC motif chemokine ligand 9
Alias:
- CXC motif chemokine 9
- chemokine (CXC motif) ligand 9
- MGC105312
- Mig
- monokine induced by gamma interferon
- Scyb9
- small inducible cytokine B9
Gene sequence:NCBI_Gene: 246759
Protein sequence:UniProtKB: Q8K4B1
Rat Cxcl9 target molecular function (prediction)
Predicted to enable CXCR3 chemokine receptor binding activity and chemokine activity. Predicted to be involved in several processes, including cellular response to lipopolysaccharide; neutrophil chemotaxis; and positive regulation of release of sequestered calcium ion into cytosol. Predicted to act upstream of or within several processes, including defense response to virus; positive regulation of myoblast differentiation; and positive regulation of myoblast fusion. Predicted to be located in external side of plasma membrane. Predicted to be active in extracellular space. Orthologous to human CXCL9 (CXC motif chemokine ligand 9).