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ANPEP molecular target information overview


  • Molecular name: ANPEP, alanyl aminopeptidase, membrane
  • Gene family: Aminopeptidases; CD molecules; M1 metallopeptidases
  • Other names: LAP1; gp150; p150
  • Former names: CD13; PEPN
  • Alias: aminopeptidase N; aminopeptidase M; microsomal aminopeptidase; membrane alanyl aminopeptidase; alanyl (membrane) aminopeptidase


    • ANPEP molecular target review


    CD13, also known as amino acid peptide N, is a member of the metalloproteinase integrin type II. CD13 is a receptor for coronaviruses that cause respiratory disease in humans and several animal species. CD13 functions as a zinc-binding metalloproteinase that modifies the N-terminal amino acids of MHC class II-bound peptides in cell surface antigen presentation. CD13 is expressed in granulocytes, monocytes and their precursors, as well as in most acute myeloid leukemias and a small fraction of acute lymphoblastic leukemias. CD13 is expressed in non-hematopoietic cells including epithelial cells, renal proximal tubules, intestinal brush borders, endothelial cells, fibroblasts, brain cells, bone marrow, osteoclasts, and bile duct lining cells.


    Human ANPEP Molecular Target Information


    Molecular name: ANPEP, alanyl aminopeptidase, membrane


    Synonyms:

    • alanyl (membrane) aminopeptidase
    • alanyl (membrane) aminopeptidase (aminopeptidase N, aminopeptidase M, microsomal aminopeptidase, CD13, p150)
    • alanyl aminopeptidase
    • aminopeptidase M
    • aminopeptidase N
    • AP-M
    • AP-N
    • APN
    • CD13
    • GP150
    • hAPN
    • LAP1
    • membrane alanyl aminopeptidase
    • microsomal aminopeptidase
    • myeloid plasma membrane glycoprotein CD13
    • P150
    • PEPN

    Gene sequence:NCBI_Gene: 290

    Protein sequence:UniProtKB: P15144


    Human ANPEP target molecular function (prediction)


    Predicted to enable metalloaminopeptidase activity; peptide binding activity; and zinc ion binding activity. Predicted to be involved in several processes, including peptide catabolic process; proteolysis; and regulation of blood pressure. Located in endoplasmic reticulum-Golgi intermediate compartment; extracellular exosome; and plasma membrane. Biomarker of severe acute respiratory syndrome.


    Mouse Anpep molecular target information


    Molecular name: Anpep, alanyl (membrane) aminopeptidase


    Alias:

    • aminopeptidase N
    • Apn
    • Cd13


    Gene sequence:NCBI_Gene: 16790

    Protein sequence:


    Mouse Anpep target molecular function (prediction)


    Predicted to enable metalloaminopeptidase activity; peptide binding activity; and zinc ion binding activity. Predicted to be involved in several processes, including negative regulation of renal sodium excretion; peptide catabolic process; and proteolysis. Predicted to act upstream of or within angiogenesis and cell differentiation. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; brain; metanephros; reproductive system; and sensory organ. Orthologous to human ANPEP (alanyl aminopeptidase, membrane).


    Rat Anpep molecular target information


    Molecular name: Anpep, alanyl aminopeptidase, membrane

    Synonyms:

    • alanyl (membrane) aminopeptidase
    • alanyl aminopeptidase
    • aminopeptidase M
    • aminopeptidase N
    • AP-M
    • AP-N
    • Apm
    • APN
    • cluster of differentiation antigen 13 (CD13)
    • kidney aminopeptidase M
    • kidney Zn peptidase
    • KZP
    • Lap1
    • leucine arylaminopeptidase 1
    • membrane alanine aminopeptidase
    • microsomal aminopeptidase
    • rAPN

    Gene sequence:NCBI_Gene: 81641

    Protein sequence:


    Rat Anpep target molecular function (prediction)


    Enables aminopeptidase activity and peptide binding activity. Involved in negative regulation of renal sodium excretion; peptide catabolic process; and proteolysis. Located in brush border membrane. Orthologous to human ANPEP (alanyl aminopeptidase, membrane).