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Overview of FASLG molecular target information


  • Molecular name: FASLG, Fas ligand
  • Gene family: CD molecules; Tumor necrosis factor superfamily; Death inducing signaling complex
  • Alias: FasL;
  • Alias:tumor necrosis factor (ligand) superfamily, member 6; Fas ligand (TNF superfamily, member 6)


    • Overview of FASLG molecular targets


    Fas ligand, also known as TNFSF6, FasL or CD95L, is a member of the tumor necrosis factor (TNF) family. It is a homotrimeric type II transmembrane protein expressed on cytotoxic T lymphocytes. Soluble Fas ligand is generated by cleavage of membrane-bound FasL by the extracellular matrix metalloproteinase MMP-7 at a conserved cleavage site. The Fas ligand/receptor interaction plays an important role in regulating the immune system and the progression of cancer. It signals through trimerization of FasR, which usually leads to apoptosis or cell death. Apoptosis caused by Fas-Fas ligand binding plays a crucial role in the regulation of the immune system, and its functions include T cell homeostasis, cytotoxic T cell activity, immune privilege, maternal tolerance and tumor counterattack. Defective Fas-mediated apoptosis can lead to tumorigenesis and drug resistance of existing tumors. Mutations in the Fas gene are associated with autoimmune lymphoproliferative syndrome (ALPS).


    Human FASLG Molecular Target Information


    Molecular name:FASLG, Fas ligand


    Alias:

    • ALPS1B
    • apoptosis (APO-1) antigen ligand 1
    • apoptosis antigen ligand
    • APT1LG1
    • APTL
    • CD178
    • CD95 ligand
    • CD95-L
    • CD95L
    • fas antigen ligand
    • Fas ligand (TNF superfamily, member 6)
    • FASL
    • mutant tumor necrosis factor family member 6
    • TNFSF6
    • TNLG1A
    • tumor necrosis factor (ligand) superfamily, member 6
    • tumor necrosis factor ligand 1A
    • tumor necrosis factor ligand superfamily member 6

    Gene sequence:NCBI_Gene: 356

    Protein sequence:UniProtKB: P48023


    Human FASLG target molecular function (prediction)


    Predicted to enable signaling receptor binding activity. Involved in several processes, including necroptotic signaling pathway; positive regulation of endothelial cell apoptotic process; and positive regulation of phosphatidylserine exposure on apoptotic cell surface. Acts upstream of or within extrinsic apoptotic signaling pathway via death domain receptors; positive regulation of apoptotic process; and neurodegenerative disease (multiple). Biomarker of several diseases, including bone marrow cancer (multiple); carcinoma (multiple); cervix uteri carcinoma in situ; clonorchiasis; and neurodegenerative disease (multiple).


    Mouse Fasl molecular target information


    Molecular Name: Fasl, Fas ligand (TNF superfamily, member 6)


    Alias:

    • APT1LG1
    • CD178
    • CD95L
    • Fas antigen ligand
    • Fas-L
    • generalized lymphoproliferative disease
    • gld
    • Tnfsf6
    • tumor necrosis factor (ligand) superfamily, member 6


    Gene sequence:NCBI_Gene: 14103

    Protein sequence:


    Mouse Fasl target molecular function (prediction)


    Predicted to enable death receptor binding activity and tumor necrosis factor receptor binding activity. Acts upstream of or within extrinsic apoptotic signaling pathway via death domain receptors and retinal cell programmed cell death. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; brain; hemolymphoid system gland; reproductive system; and trophectoderm. Used to study autoimmune lymphoproliferative syndrome and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including cholangiocarcinoma; chronic myeloid leukemia; diabetes mellitus (multiple); pancreatic cancer (multiple); and pre-eclampsia (multiple). Orthologous to human FASLG (Fas ligand).


    Rat Faslg molecular target information


    Molecular name: Faslg, Fas ligand

    Alias:

    • apoptosis (APO-1) antigen ligand 1 (Fas antigen ligand)
    • Apt1Lg1
    • CD95 ligand
    • CD95-L
    • CD95L protein
    • Fas antigen ligand
    • Fas ligand (TNF superfamily, member 6)
    • Fasl
    • Tnfsf6
    • Tnlg1a
    • Tumor necrosis factor (ligand) superfamily member 6 (apoptosis (APO-1) antigen ligand 1) (Fas antigen ligand)
    • tumor necrosis factor (ligand) superfamily, member 6
    • Tumor necrosis factor (ligand) superfamily, member 6 (apoptosis (APO-1) antigen ligand 1) (Fas antigen ligand)
    • tumor necrosis factor ligand 1a
    • tumor necrosis factor ligand superfamily member 6

    Gene sequence:NCBI_Gene: 25385

    Protein sequence:


    Rat Faslg target molecular function (prediction)


    Enables death receptor binding activity and tumor necrosis factor receptor binding activity. Involved in several processes, including cellular ion homeostasis; cellular response to interferon-gamma; and extrinsic apoptotic signaling pathway via death domain receptors. Located in caveola; cytoplasmic vesicle; including artery disease (multiple); chronic obstructive pulmonary disease; gastric ulcer; liver disease (multiple); and ulcerative colitis. Human ortholog(s) of this gene implicated in several diseases, including cholangiocarcinoma; chronic myeloid leukemia; diabetes mellitus (multiple); pancreatic cancer (multiple); and pre-eclampsia (multiple). Orthologous to human FASLG (Fas ligand).