CD86 molecular target information overview
CD86 molecular target review
CD86, also known as B7.2, has a molecular weight of 80 kD and is expressed in dendritic cells, monocytes, memory T lymphocytes, germinal center B lymphocytes, activated B lymphocytes, and activated T lymphocytes. It belongs to the immunoglobulin superfamily, and its ligands are CD28 and CD152 (CTLA4). CD86 interacts with the inducer CD28 and the inhibitor CTLA4, and is the main synergistic factor that induces T lymphocyte proliferation and produces IL-2.
Human CD86 Molecular Target Information
Molecular name: CD86, CD86 molecule
Alias:
- activation B7-2 antigen
- B-lymphocyte activation antigen B7-2
- B-lymphocyte antigen B7-2
- B7-2
- B7-2 antigen
- B7.2
- B70
- BU63
- CD28 antigen ligand 2
- CD28LG2
- CD86 antigen (CD28 antigen ligand 2, B7-2 antigen)
- CTLA-4 counter-receptor B7.2
- FUN-1
- LAB72
- MGC34413
- T-lymphocyte activation antigen CD86
Gene sequence:NCBI_Gene: 942
Protein sequence:UniProtKB: P42081
Human CD86 target molecule function (prediction)
Predicted to enable signaling receptor activity. Predicted to be involved in several processes, including CD40 signaling pathway; positive regulation of macromolecule metabolic process; and regulation of T cell activation. Predicted to act upstream of or within defense response to virus and toll-like receptor signaling pathway. Located in centriolar satellite; extracellular exosome; leukemia; chronic obstructive pulmonary disease; and systemic scleroderma. Biomarker of several diseases, including autoimmune disease (multiple); cryoglobulinemia; hematologic cancer (multiple); lung disease (multiple); and pulmonary hypertension.
Mouse Cd86 molecular target information
Molecular name: Cd86, CD86 antigen
Alias:
- B7-2
- B7.2
- B70
- CD28 antigen ligand
- Cd28l2
- Ly-58
- Ly58
- lymphocyte antigen 58
- MB7-2
Gene sequence:NCBI_Gene: 12524
Protein sequence:
- UniprotKB: P42082
- UniprotKB: A0A0X9RAD7
- UniprotKB: Q3T9F8
- UniprotKB: Q3TDR5
- UniprotKB: Q549Q9
- UniprotKB: Q61238
- UniprotKB: Q91YV7
Mouse Mouse Cd86 Target Molecular Function (Prediction)
Predicted to enable signaling receptor binding activity. Involved in several processes, including CD40 signaling pathway; activation of phospholipase C activity; and positive regulation of macromolecule metabolic process. Acts upstream of or within several processes, including cellular response to lipopolysaccharide; defense response to virus; and positive regulation of T cell proliferation. Located in external side of plasma membrane and intracellular membrane-bounded organelle. Is expressed in central nervous system and retina. Used to study Guillain-Barre syndrome. Human ortholog(s) of this gene implicated in several diseases, including Henoch-Schoenlein purpura; autoimmune disease (multiple); chronic lymphocytic leukemia; chronic obstructive pulmonary disease; and systemic scleroderma. Orthologous to human CD86 (CD86 molecule).
Rat Cd86 molecular target information
Molecular name: Cd86, CD86 molecule
Alias:
- B7-2
- cd86 antigen
- membrane glycoprotein
- T-lymphocyte activation antigen CD86
Gene sequence:NCBI_Gene: 56822
Protein sequence:
Rat Cd86 target molecular function (prediction)
Enables signaling receptor binding activity. Involved in several processes, including defense response to other organism; negative regulation of T cell anergy; and positive regulation of activated T cell proliferation. Located in cell surface. Used to study adult T-cell leukemia and bronchiolitis obliterans. Biomarker of asthma; corneal disease; middle cerebral artery infarction; and orchitis. Human ortholog(s) of this gene implicated in several diseases, including Henoch-Schoenlein purpura; autoimmune disease (multiple); chronic lymphocytic leukemia; chronic obstructive pulmonary disease; and systemic scleroderma. Orthologous to human CD86 (CD86 molecule).