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KMT2A molecular target information overview


  • Molecular name: KMT2A, lysine methyltransferase 2A
  • Gene family: PHD finger proteins; Zinc fingers CXXC-type; Lysine methyltransferases; Bromodomain containing; SET domain containing
  • Alias: TRX1; MLL1A; MLL1; ALL1; HTRX
  • Former name: MLL
  • Alias: Histone-lysine N-methyltransferase 2A; myeloid/lymphoid or mixed-lineage leukemia (trithorax (Drosophila) homolog); myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); lysine (K)-specific methyltransferase 2A; Trithorax-like protein; CXXC-type zinc finger protein 7; Acute lymphocytic 1


    • KMT2A molecular target review


    Thioredoxins (Trxs) are a group of small proteins that are widely present in all living cells and are key regulators of cellular redox balance. The mammalian Trx family has three members: Trx-1, Trx-2, and TrxL. Trx-1 is the only thioredoxin that exists outside the cell and is secreted by lymphocytes, hepatocytes, fibroblasts, and a variety of tumor cells. The concentration of Trx-1 in plasma can reach 6 nM. It is mainly present in the cytoplasm of cells, with a small amount in the nucleus and in areas associated with the extracellular surface. The expression of Trx-1 increases under various stress conditions such as hypoxia, elevated hydrogen peroxide concentrations, photochemical oxidative stress, and viral and bacterial infections. The biological functions of Trx-1 include growth factor activity, antioxidant properties, cofactors that provide reducing equivalents, and transcriptional regulation. The synovial tissue of patients with rheumatoid arthritis has increased levels of Trx-1 under oxidative stress conditions. The level of Trx-1 in plasma is associated with the severity of the disease, indicating that Trx-1 can be used as a biomarker for pathological conditions.


    Human KMT2A Molecular Target Information


    Molecular name: KMT2A, lysine methyltransferase 2A


    Alias:

    • ALL-1
    • CDK6/MLL fusion protein
    • CXXC-type zinc finger protein 7
    • CXXC7
    • FLJ11783
    • histone-lysine N-methyltransferase 2A
    • histone-lysine N-methyltransferase MLL
    • HRX
    • HTRX1
    • hypothetical protein FLJ11783
    • lysine (K)-specific methyltransferase 2A
    • lysine N-methyltransferase 2A
    • mixed lineage leukemia 1
    • MLL
    • MLL-AF4 der(11) fusion protein
    • MLL-AF9
    • MLL/GAS7
    • MLL/GAS7 fusion protein
    • MLL/GMPS fusion protein
    • MLL1
    • MLL1A
    • myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)
    • myeloid/lymphoid or mixed-lineage leukemia protein 1
    • TET1-MLL
    • trithorax-like protein
    • TRX1
    • WDSTS
    • zinc finger protein HRX

    Gene sequence:NCBI_Gene: 4297

    Protein sequence: UniProtKB: Q03164


    Human KMT2A target molecular function (prediction)


    Enables several functions, including lysine-acetylated histone binding activity; protein homodimerization activity; and protein methyltransferase activity. Involved in several processes, including histone modification; positive of transporter activity; and regulation of nucleobase-containing compound metabolic process. Located in cytosol and nucleoplasm. Part of MLL1 complex. Implicated in acute myeloid leukemia; cervical cancer; mixed phenotype acute leukemia; and non-Hodgkin lymphoma. Biomarker of prostate cancer.


    Mouse Kmt2a molecular target information


    Molecular Name: Kmt2a, lysine (K)-specific methyltransferase 2A


    Alias:

    • acute lymphocytic leukemia
    • ALL-1
    • All1
    • Cxxc7
    • HTRX1
    • Mll
    • Mll1
    • myeloid/lymphoid or mixed-lineage leukemia
    • myeloid/lymphoid or mixed-lineage leukemia 1
    • trithorax Drosophila


    Gene sequence:NCBI_Gene: 214162

    Protein sequence:


    Mouse Kmt2a target molecular function (prediction)


    Acts upstream of or within several processes, including hematopoietic or lymphoid organ development; macromolecule methylation; and regulation of histone modification. Located in nucleus. Is expressed in several structures, including extraembryonic component; genitourinary component hematopoietic system; nervous system; and retina. Used to study acute lymphoblastic leukemia and acute myeloid leukemia. Human ortholog(s) of this gene implicated in acute myeloid leukemia; cervical cancer; mixed phenotype acute leukemia; and non-Hodgkin lymphoma. Orthologous to human KMT2A (lysine methyltransferase 2A).


    Rat Kmt2a molecular target information


    Molecular name: Kmt2a, lysine methyltransferase 2A

    Alias:

    • histone-lysine N-methyltransferase 2A
    • histone-lysine N-methyltransferase MLL
    • lysine (K)-specific methyltransferase 2A
    • Mixed-lineage leukemia (also acute lymphocytic leukemia 1 or trithorax Drosophila gene)
    • Mixed-lineage leukemia (also acute lymphocytic leukemia 1 or tritorax Drosophila gene)
    • Mll
    • Mll_mapped
    • Mll1
    • myeloid/lymphoid or mixed-lineage leukemia
    • myeloid/lymphoid or mixed-lineage leukemia (mapped)
    • myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)
    • myeloid/lymphoid or mixed-lineage leukemia 1

    Gene sequence:NCBI_Gene: 315606

    Protein sequence:UniProtKB: F1M0L3


    Rat Kmt2a target molecular function (prediction)


    Predicted to enable protein C-terminus binding activity. Involved in several processes, including DNA metabolic process; animal organ regeneration; and cellular response to heat. Located in nucleus. Used to study high grade glioma; leiomyoma; and prostate carcinoma. Biomarker of colon cancer; kidney disease; mucositis; type 2 diabetes mellitus; immunodeficiency virus infectious disease; and pancreatic cancer. Orthologous to human MKI67 (marker of proliferation Ki-67).