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EGFR molecular target information overview


  • Molecular name: EGFR, epidermal growth factor receptor
  • Gene family: Erb-b2 receptor tyrosine kinases
  • Alias: ERBB1; ERRP
  • Previous name: ERBB
  • Alias: erythroblastic leukemia viral (v-erb-b) oncogene homolog (avian); erb-b2 receptor tyrosine kinase 1; epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)


    • Overview of EGFR molecular targets


    Epidermal growth factor receptor (EGFR), also known as ErbB1 and HER1, is a type I transmembrane glycoprotein. It is present on the cell surface and is activated by binding to its specific ligands, including EGF and TGF-α. EGFR signaling plays an important role in regulating cell proliferation, survival, and differentiation. Upon binding to the ligand, EGFR induces homo- or heterodimerization, which in turn triggers subsequent tyrosine autophosphorylation and multiple downstream pathways (MAPK, PI3K/PKB, and STAT). Activation of this receptor plays an important role in the innate immune response of human skin, and EGFR overexpression (upregulation) or excessive activity is associated with many cancers, including lung cancer, anal cancer, and glioblastoma multiforme. Abnormal EGFR signaling is associated with psoriasis, eczema, and atherosclerosis, and researchers currently believe that EGFR can be used as a target for cancer treatment.


    Human EGFR Molecular Target Information


    Molecular name:EGFR, epidermal growth factor receptor


    Alias:

    • avian erythroblastic leukemia viral (v-erb-b) oncogene homolog
    • cell growth inhibiting protein 40
    • cell proliferation-inducing protein 61
    • EGFR vIII
    • epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
    • epidermal growth factor receptor tyrosine kinase domain
    • erb-b2 receptor tyrosine kinase 1
    • ERBB
    • ERBB1
    • ERRP
    • erythroblastic leukemia viral (v-erb-b) oncogene homolog
    • HER1
    • mENA
    • NISBD2
    • PIG61
    • proto-oncogene c-ErbB-1
    • receptor tyrosine-protein kinase erbB-1

    Gene sequence:NCBI_Gene: 1956

    Protein sequence:UniProtKB: P00533


    Human EGFR target molecular function (prediction)


    Acts upstream of or within epidermal growth factor receptor signaling pathway and positive regulation of cell population proliferation. Located in several cellular components, including basolateral plasma membrane; endosome; and membrane raft. Part of receptor complex. Is active in ruffle membrane. Colocalizes with endosome. Implicated in several diseases, including colorectal cancer; lung non-small cell carcinoma (multiple); pancreatic cancer; prostate cancer; and pulmonary tuberculosis.


    Mouse Egfr molecular target information


    Molecular name:Egfr, epidermal growth factor receptor


    Alias:

    • 9030024J15Rik
    • AI552599
    • avian erythroblastic leukemia viral (v-erb-b) oncogene homolog
    • avian erythroblastosis oncogene B
    • Erbb
    • Errb1
    • expressed sequence AI552599
    • RIKEN cDNA 9030024J15 gene
    • wa-2
    • wa2
    • Wa5
    • waved 2
    • waved 5


    Gene sequence:NCBI_Gene: 13649

    Protein sequence:


    Mouse Egfr target molecular function (prediction)


    Enables epidermal growth factor binding activity and epidermal growth factor-activated receptor activity. Involved in cellular response to amino acid stimulus and positive regulation of fibroblast proliferation. Acts upstream of or within several processes, including animal organ development; epidermal growth factor receptor signaling pathway; and protein autophosphorylation. Located in several cellular components, including basolateral plasma membrane; endocytic vesicle; and perinuclear region of cytoplasm. Is expressed in several structures, including alimentary system; brain; integral system; limb; and respiratory system. Used to study Coronavirus infectious disease and aortic valve disease. Human ortholog(s) of this gene implicated in several diseases, including colorectal cancer; lung non-small cell carcinoma (multiple); pancreatic cancer; prostate cancer; and pulmonary tuberculosis. Orthologous to human EGFR (epidermal growth factor receptor).


    Rat Egfr molecular target information


    Molecular name:Egfr, epidermal growth factor receptor

    Synonyms:

    • avian erythroblastic leukemia viral (v-erbB) oncogene homolog
    • Egfr-related peptide
    • Epidermal growth factor receptor formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1)
    • Epidermal growth factor receptor, formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1)
    • ErbB-1
    • ERBB1
    • Errp

    Gene sequence:NCBI_Gene: 24329

    Protein sequence:


    Rat Egfr target molecular function (prediction)


    Enables several functions, including calmodulin binding activity; epidermal growth factor binding activity; and epidermal growth factor-activated receptor activity. Involved in several processes, including animal organ development; neurogenesis; and positive regulation of cell communication. Located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and cytoplasmic vesicle. Used to study bronchiolo-alveolar adenocarcinoma; dilated cardiomyopathy; and high grade glioma. Biomarker of several diseases, including Parkinsonism; acute kidney failure; lung disease (multiple); median neuropathy; and peptic esophagitis. Human ortholog(s) of this gene implicated in several diseases, including colorectal cancer; lung non-small cell carcinoma (multiple); pancreatic cancer; prostate cancer;