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CFH molecular target information overview


  • Molecular name: CFH, complement factor H
  • Gene family: Sushi domain containing; Complement system regulators and receptors
  • Alias: HUS; FHL1; ARMS1; ARMD4
  • Previous names: HF; HF1; HF2
  • Alias: beta-1H; H factor 2 (complement); age-related maculopathy susceptibility 1; H factor 1 (complement)


    • Overview of CFH molecular targets


    Complement factor H, also known as factor H 1 and CFH, is a sialic acid-containing glycoprotein that plays an integral role in regulating the complement-mediated immune system involved in microbial defense, immune complex processing, and programmed cell death. CFH acts as a regulator of the alternative pathway of the complement system by ensuring that the relevant immune response acts on foreign pathogens that are not host cells. CFH protects self cells from complement activation, but not bacteria and viruses. Misregulation of CFH may adversely affect the ability to deal with foreign infections or reduce complement activity in host cells. Mutations in the factor H gene are associated with a variety of serious diseases, including the rare kidney diseases hemolytic uremic syndrome (HUS) and membranoproliferative glomerulonephritis (MPGN), also known as dense deposit disease (DDD), membranoproliferative glomerulonephritis type II or dense deposit disease, and the more common age-related macular degeneration (AMD).


    Human CFH Molecular Target Information


    Molecular name: CFH, complement factor H


    Alias:

    • adrenomedullin binding protein
    • age-related maculopathy susceptibility 1
    • AHUS1
    • AMBP1
    • ARMD4
    • ARMS1
    • beta-1-H-globulin
    • beta-1H
    • CFHL3
    • complement factor H, isoform b
    • factor H
    • factor H-like 1
    • FH
    • FHL1
    • H factor 1 (complement)
    • H factor 2 (complement)
    • HF
    • HF1
    • HF2
    • HUS
    • MGC88246

    Gene sequence:NCBI_Gene: 3075

    Protein sequence: UniProtKB: P08603


    Human CFH target molecular function (prediction)


    Enables heparan sulfate proteoglycan binding activity; heparin binding activity; and identical protein binding activity. Involved in complement activation. Acts upstream of or within regulation of complement activation and of complement-dependent cytotoxicity. Located in blood microparticle and extracellular exo regulation. Implicated in several diseases, including atypical hemolytic-uremic syndrome; eye disease (multiple); hemolytic-uremic syndrome; lupus nephritis; and systemic lupus erythematosus. Biomarker of amphetamine abuse; atypical hemolytic-uremic syndrome; glaucoma; psoriasis; and squamous cell carcinoma.


    Mouse Cfh molecular target information


    Molecular name: Cfh, complement component factor h


    Alias:

    • Mud-1
    • Sas-1
    • Sas1
    • serum antigenic substance 1


    Gene sequence:NCBI_Gene: 12628

    Protein sequence:


    Mouse Cfh target molecular function (prediction)


    Acts upstream of or within several processes, including animal organ development; activation complement; and vasculature development. Located in several cellular components, including axon; external side of plasma membrane; and neuronal cell body. Is expressed in several structures, including adrenal gland; bone; central nervous system; humerus cartilage condensation; and metanephros. Used to study age related macular degeneration 4; atypical hemolytic-uremic syndrome; hemolytic-uremic syndrome; and membranoproliferative glomerulonephritis. Human ortholog(s) of this gene implicated in several diseases, including atypical hemolytic-uremic syndrome; eye disease (multiple); hemolytic-uremic syndrome; lupus nephritis; and systemic lupus erythematosus. Orthologous to several human genes including CFH (complement factor H).


    Rat Cfh molecular target information


    Molecular name: Cfh, complement factor H

    Alias:

    • adrenomedullin binding protein-1
    • AMBP-1
    • AMBP1
    • complement component factor H
    • complement inhibitory factor H
    • Fh
    • platelet complement factor H

    Gene sequence:NCBI_Gene: 155012

    Protein sequence:


    Rat Cfh target molecular function (prediction)


    Predicted to enable several functions, including complement component C3b binding activity; heparan sulfate proteoglycan binding activity; and heparin binding activity. Involved in several processes, including cellular response to hydrogen peroxide; cellular response to interferon-gamma; and cellular response to lipopolysaccharide. Located in several cellular components, including extracellular space; nucleus; abuse; membranous glomerulonephritis; obstructive jaundice; proteinuria (multiple); and retinal degeneration. Human ortholog(s) of this gene implicated in several diseases, including atypical hemolytic-uremic syndrome; eye disease (multiple); hemolytic-uremic syndrome; lupus nephritis; and systemic lupus erythematosus. Orthologous to several human genes including CFH (complement factor H).