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CA12 Molecular Target Information Overview


  • Molecular name: CA12, carbonic anhydrase 12
  • Gene family: Carbonic anhydrases
  • Alias: HsT18816
  • Alias: carbonic anhydrase XII


    • CA12 molecular target review


    Carbonic anhydrases are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. Carbonic anhydrases are involved in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. Carbonic anhydrase 12 (CA12) is a type I membrane protein that is highly expressed in normal tissues such as the kidney, colon, and pancreas and is overexpressed in 10% of renal clear cell carcinomas. Two transcript variants encoding different isoforms of CA12 have been identified. Because sweating depletes salt, researchers believe that mutations in the CA12 gene are associated with autosomal recessive hyponatremia.


    Human CA12 Molecular Target Information


    Molecular name: CA12, carbonic anhydrase 12


    Alias:

    • CA-XII
    • carbonate dehydratase XII
    • carbonic anhydrase XII
    • carbonic dehydratase
    • CAXII
    • FLJ20151
    • HsT18816
    • T18816
    • tumor antigen HOM-RCC-3.1.3

    Gene sequence:NCBI_Gene: 771

    Protein sequence:UniProtKB: O43570


    Human CA12 target molecular function (prediction)


    Predicted to enable carbonate dehydratase activity. Involved in chloride ion homeostasis. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Implicated in isolated hyperchlorhidrosis.


    Mouse Car12 molecular target information


    Molecular name: Car12, carbonic anhydrase 12


    Alias:

    • 2310047E01Rik
    • AI314958
    • CA XII
    • expressed sequence AI314958
    • RIKEN cDNA 2310047E01 gene


    Gene sequence:NCBI_Gene: 76459

    Protein sequence:


    Mouse Car12 target molecular function (prediction)


    Enables carbonate dehydratase activity. Predicted to be involved in chloride ion homeostasis and one-carbon metabolic process. Predicted to act upstream of or within carbon dioxide transport and of pH. Predicted to be located in membrane. Predicted to be integral component of regulation membrane. Predicted to be active in plasma membrane. Ortholog(s) of this gene implicated in isolated hyperchlorhidrosis. Orthologous to human CA12 (carbonic anhydrase 12).


    Rat Ca12 molecular target information


    Molecular name: Ca12, carbonic anhydrase 12

    Alias:

    • Car12
    • carbonic anyhydrase 12
    • LOC363085
    • membrane-bound carbonic anhydrase 12

    Gene sequence:NCBI_Gene: 363085

    Protein sequence:UniProtKB: A2IBE2


    Rat Ca12 target molecular function (prediction)


    Predicted to enable carbonate dehydratase activity. Predicted to be involved in chloride ion homeostasis and one-carbon metabolic process. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in isolated hyperchlorhidrosis. Orthologous to human CA12 (carbonic anhydrase 12).