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CHI3L1 Molecular Target Information Overview


  • Molecular name: CHI3L1, chitinase 3 like 1
  • Gene family: Chitinases
  • Aliases: GP39; YKL40; YK-40
  • Alias: cartilage glycoprotein-39; chitinase 3-like 1 (cartilage glycoprotein-39)


    • CHI3L1 molecular target review


    Chitinase 3-like protein 1 (CHI3L1) is secreted by many cell types, including macrophages, chondrocytes, and certain tumor cells. The exact physiological function of CHI3L1 is unknown, but it is involved in developmental and inflammatory diseases, such as asthma and tumors. CHI3L1 is a Th2-promoting cytokine that is expressed at high levels in the tumor microenvironment and serum of cancer patients. Elevated CHI3L1 expression is strongly correlated with the development stage and outcome of multiple tumor types, suggesting that CHI3L1 can be used as a biomarker for disease severity. Treatment with neutralizing antibodies to CHI3L1 is effective in animal models of glioblastoma multiforme. CHI3L1 can promote angiogenesis through VEGF-dependent and -independent pathways. CHI3L1 can also enhance tumor survival under gamma irradiation.


    Human CHI3L1 Molecular Target Information


    Molecular name: CHI3L1, chitinase 3 like 1


    Alias:

    • 39 kDa synovial protein
    • ASRT7
    • cartilage glycoprotein 39
    • CGP-39
    • chitinase 3-like 1 (cartilage glycoprotein-39)
    • chitinase-3-like protein 1
    • DKFZp686N19119
    • FLJ38139
    • GP-39
    • GP39
    • HC-gp39
    • hCGP-39
    • HCGP-3P
    • YK-40
    • YKL-40
    • YKL40
    • YYL-40

    Gene sequence:NCBI_Gene: 1116

    Protein sequence:UniProtKB: P36222


    Human CHI3L1 target molecular function (prediction)


    Enables chitin binding activity. Involved in several processes, including positive regulation of intracellular signal transduction; response to interleukin-1; and response to interleukin-6. Located in extracellular space. Implicated in asthma and schizophrenia. Biomarker of several diseases, including artery disease (multiple); autoimmune disease (multiple); bone cancer (multiple); lung disease (multiple); and organ reproductive cancer (multiple).


    Mouse Chil1 molecular target information


    Molecular name: Chil1, chitinase-like 1


    Alias:

    • AW208766
    • Brp39
    • Chi3l1
    • chitinase 3-like 1
    • expressed sequence AW208766
    • glycoprotein 39
    • Gp39


    Gene sequence:NCBI_Gene: 12654

    Protein sequence:


    Mouse Chil1 target molecular function (prediction)


    Predicted to enable chitin binding activity. Involved in positive regulation of interleukin-8 production; positive regulation of protein kinase B signaling; and positive regulation of protein phosphorylation. Located in endoplasmic reticulum. Is expressed in alimentary system;


    Rat Chi3l1 molecular target information


    Molecular name: Chi3l1, chitinase 3 like 1

    Other Names:

    • cartilage glycoprotein 39
    • CGP-39
    • Chil1
    • chitinase 3-like 1
    • chitinase 3-like 1 (cartilage glycoprotein-39)
    • chitinase-3-like protein 1
    • GP-39
    • MGC109420

    Gene sequence:NCBI_Gene: 89824

    Protein sequence:


    Rat Chi3l1 target molecular function (prediction)


    Predicted to enable chitin binding activity. Involved in cellular response to interleukin-1; cellular response to tumor necrosis factor; and inflammatory response. Located in extracellular space. Biomarker of hypertension. Human ortholog(s) of this gene implicated in asthma and schizophrenia. Orthologous to human CHI3L1 (chitinase 3 like 1).