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TNFSF10 molecular target information overview


  • Molecular name: TNFSF10, TNF superfamily member 10
  • Gene family: CD molecules; Tumor necrosis factor superfamily
  • Alias: TRAIL; Apo-2L; TL2; CD253
  • Alias: tumor necrosis factor (ligand) superfamily, member 10


    • Overview of TNFSF10 molecular targets


    Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), also known as CD253 or TNFSF10, is produced and secreted by most normal tissue cells. TRAIL binds to the death receptors DR4 (TRAIL-RI) and DR5 (TRAIL-RII). The process of apoptosis is dependent on caspase-8. Caspase-8 activates downstream caspases, including procaspase-3, 6, and 7, which activate specific kinases. TRAIL can also bind to the receptor DcR1 that does not contain a cytoplasmic region and the receptor DcR2 that contains a truncated death domain. DcR1 can act as a TRAIL neutralizing receptor. The cytoplasmic region of DcR2 is functional and can activate NF-κB. Therefore, in cells expressing DcR2, the binding of TRAIL activates NF-κB, resulting in the transcription of genes that antagonize the death signaling pathway and/or promote inflammation.


    Human TNFSF10 Molecular Target Information


    Molecular name: TNFSF10, TNF superfamily member 10


    Alias:

    • Apo-2 ligand
    • Apo-2L
    • APO2L
    • CD253
    • chemokine tumor necrosis factor ligand superfamily member 10
    • TL2
    • TNF-related apoptosis inducing ligand TRAIL
    • TNF-related apoptosis-inducing ligand
    • TNLG6A
    • TRAIL
    • tumor necrosis factor (ligand) family, member 10
    • tumor necrosis factor (ligand) superfamily member 10
    • tumor necrosis factor (ligand) superfamily, member 10
    • tumor necrosis factor apoptosis-inducing ligand splice variant delta
    • tumor necrosis factor ligand 6A
    • tumor necrosis factor ligand superfamily member 10
    • tumor necrosis factor superfamily member 10

    Gene sequence:NCBI_Gene: 8743

    Protein sequence:UniProtKB: P50591


    Human TNFSF10 target molecular function (prediction)


    Enables identical protein binding activity and zinc ion binding activity. Involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of release of cytochrome c from mitochondria; and positive regulation of signal transduction. Located in extracellular exosome. Implicated in arteriosclerosis and small cell carcinoma. Biomarker of type 1 diabetes mellitus.


    Mouse Tnfsf10 molecular target information


    Molecular name:Tnfsf10, tumor necrosis factor (ligand) superfamily, member 10


    Alternate names:

    • A330042I21Rik
    • AI448571
    • APO-2L
    • expressed sequence AI448571
    • RIKEN cDNA A330042I21 gene
    • TNF-related apoptosis inducing ligand
    • Trail


    Gene sequence:NCBI_Gene: 22035

    Protein sequence:


    Mouse Tnfsf10 target molecular function (prediction)


    Enables TRAIL binding activity and tumor necrosis factor receptor superfamily binding activity. Acts upstream of or within positive regulation of extrinsic apoptotic signaling pathway. Predicted to be located in extracellular space and plasma membrane. Predicted to be integral component of membrane. Is expressed in central nervous system; genitourinary system; gut; and retina. Human ortholog(s) of this gene implicated in arteriosclerosis and small cell carcinoma. TNFSF10 (TNF superfamily member 10).


    Rat Tnfsf10 molecular target information


    Molecular name: Tnfsf10, TNF superfamily member 10

    Alias:

    • 4-1BB
    • LOC500590
    • MGC114552
    • similar to T-cell antigen 4-1BB precursor - mouse
    • tumor necrosis factor receptor superfamily, member 9
    • tumor necrosis factor receptor superfamily, member 9

    Gene sequence:NCBI_Gene: 246775

    Protein sequence:UniProtKB: E9PU84


    Rat Tnfsf10 target molecular function (prediction)


    Predicted to enable cytokine binding activity; identical protein binding activity; and signaling receptor activity. Predicted to be involved in regulation of cell population proliferation. Predicted to act upstream of or within negative regulation of interleukin-10 production and negative regulation of interleukin-12 production. Predicted to be located in extracellular space and plasma membrane. Predicted to be active in external side of plasma membrane. Orthologous to human TNFRSF9 (TNF receptor superfamily member 9).